The nucleophosmin (NPM1) gene encodes for a multifunctional protein with prominent
nucleolar localization that shuttles between nucleus and cytoplasm. NPM1 mutations …

Clonal diversity is a consequence of cancer cell evolution driven by Darwinian selection.
Precise characterization of clonal architecture is essential to understand the evolutionary …

Acute myeloid leukaemia (AML) is a rare but severe form of human cancer that results from a
limited number of functionally cooperating genetic abnormalities leading to uncontrolled …

NPM1 is the most frequently mutated gene in cytogenetically normal acute myeloid leukemia
(AML). In AML cells, NPM1 mutations result in abnormal cytoplasmic localization of the …

The initiating mutations that contribute to cancer development are sometimes present in
premalignant cells. Whether therapies targeting these mutations can eradicate premalignant …

Long non-coding RNAs (lncRNAs) are critical for regulating HOX genes, aberration of which
is a dominant mechanism for leukemic transformation. How HOX gene-associated lncRNAs …

Long non-coding RNAs (lncRNAs) are important regulatory molecules that are implicated in
cellular physiology and pathology. In this work, we dissect the functional role of the HOXB …

Nucleophosmin (NPM1) is among the most frequently mutated genes in acute myeloid
leukemia (AML). It is not known, however, how the resulting oncoprotein mutant NPM1 is …

Acute myeloid leukemia (AML) with NPM1 mutation (NPM1 mut) defines a World Health
Organization entity. Absence of minimal residual disease (MRD) following induction …

In acute myeloid leukemia (AML), molecular heterogeneity across patients constitutes a
major challenge for prognosis and therapy. AML with NPM1 mutation is a distinct genetic …