Chemical space of DNA-encoded libraries: Miniperspective
RM Franzini, C Randolph - Journal of medicinal chemistry, 2016 - ACS Publications
In recent years, DNA-encoded chemical libraries (DECLs) have attracted considerable
attention as a potential discovery tool in drug development. Screening encoded libraries …
attention as a potential discovery tool in drug development. Screening encoded libraries …
[HTML][HTML] The challenge of peptide nucleic acid synthesis
KP Nandhini, D Al Shaer, F Albericio… - Chemical Society …, 2023 - pubs.rsc.org
Peptide nucleic acids (PNAs) are an important class of DNA/RNA mimics that can hybridize
complementary chains of nucleic acids with high affinity and specificity. Because of this …
complementary chains of nucleic acids with high affinity and specificity. Because of this …
What is a “DNA-compatible” reaction?
ML Malone, BM Paegel - ACS combinatorial science, 2016 - ACS Publications
DNA-encoded synthesis can generate vastly diverse screening libraries of arbitrarily
complex molecules as long as chemical reaction conditions do not compromise DNA's …
complex molecules as long as chemical reaction conditions do not compromise DNA's …
[HTML][HTML] Identification of immunodominant linear epitopes from SARS-CoV-2 patient plasma
A novel severe acute respiratory syndrome coronavirus (SARS-CoV-2) is the source of a
current pandemic (COVID-19) with devastating consequences in public health and …
current pandemic (COVID-19) with devastating consequences in public health and …
An overview of DNA-encoded libraries: A versatile tool for drug discovery
D Madsen, C Azevedo, I Micco, LK Petersen… - Progress in medicinal …, 2020 - Elsevier
DNA-encoded libraries (DELs) are collections of small molecules covalently attached to
amplifiable DNA tags carrying unique information about the structure of each library …
amplifiable DNA tags carrying unique information about the structure of each library …
Micellar Brønsted acid mediated synthesis of DNA-tagged heterocycles
MK Škopić, K Gotte, C Gramse, M Dieter… - Journal of the …, 2019 - ACS Publications
The translation of well-established molecular biology methods such as genetic coding,
selection, and DNA sequencing to combinatorial organic chemistry and compound …
selection, and DNA sequencing to combinatorial organic chemistry and compound …
Ruthenium promoted on-DNA ring-closing metathesis and cross-metathesis
DNA-encoded library technology (ELT) is now widely used in pharmaceutical,
biotechnological, and academic research for hit identification and target validation. New on …
biotechnological, and academic research for hit identification and target validation. New on …
Versatility of peptide nucleic acids (PNA s): Role in chemical biology, drug discovery, and origins of life
C Sharma, SK Awasthi - Chemical biology & drug design, 2017 - Wiley Online Library
This review briefly discussed nomenclature, synthesis, chemistry, and biophysical properties
of a plethora of PNA derivatives reported since the discovery of aeg PNA. Different synthetic …
of a plethora of PNA derivatives reported since the discovery of aeg PNA. Different synthetic …
Coupling of DNA circuit and templated reactions for quadratic amplification and release of functional molecules
DNA-based circuitry empowers logic gated operations and amplifications but is restricted to
nucleic acid output. Templated reactions enable the translation of nucleic acid cues into …
nucleic acid output. Templated reactions enable the translation of nucleic acid cues into …
Self-assembled antibody multimers through peptide nucleic acid conjugation
SA Kazane, JY Axup, CH Kim, M Ciobanu… - Journal of the …, 2013 - ACS Publications
With the recent clinical success of bispecific antibodies, a strategy to rapidly synthesize and
evaluate bispecific or higher order multispecific molecules could facilitate the discovery of …
evaluate bispecific or higher order multispecific molecules could facilitate the discovery of …