In recent years, DNA-encoded chemical libraries (DECLs) have attracted considerable
attention as a potential discovery tool in drug development. Screening encoded libraries …

Peptide nucleic acids (PNAs) are an important class of DNA/RNA mimics that can hybridize
complementary chains of nucleic acids with high affinity and specificity. Because of this …

DNA-encoded synthesis can generate vastly diverse screening libraries of arbitrarily
complex molecules as long as chemical reaction conditions do not compromise DNA's …

A novel severe acute respiratory syndrome coronavirus (SARS-CoV-2) is the source of a
current pandemic (COVID-19) with devastating consequences in public health and …

DNA-encoded libraries (DELs) are collections of small molecules covalently attached to
amplifiable DNA tags carrying unique information about the structure of each library …

The translation of well-established molecular biology methods such as genetic coding,
selection, and DNA sequencing to combinatorial organic chemistry and compound …

DNA-encoded library technology (ELT) is now widely used in pharmaceutical,
biotechnological, and academic research for hit identification and target validation. New on …

This review briefly discussed nomenclature, synthesis, chemistry, and biophysical properties
of a plethora of PNA derivatives reported since the discovery of aeg PNA. Different synthetic …

DNA-based circuitry empowers logic gated operations and amplifications but is restricted to
nucleic acid output. Templated reactions enable the translation of nucleic acid cues into …

With the recent clinical success of bispecific antibodies, a strategy to rapidly synthesize and
evaluate bispecific or higher order multispecific molecules could facilitate the discovery of …