Alzheimer's disease (AD) is the leading cause of dementia, predicted to be the most
significant health burden of the 21st century, with an estimated 131.5 million dementia …

Protein misfolding diseases (PMDs) are chronic and progressive, with no effective therapy
so far. Aggregation and misfolding of amyloidogenic proteins are closely associated with the …

Epidemiological studies indicate that the consumption of caffeine, the most commonly
ingested psychoactive substance found in coffee, tea or soft drinks, reduces the risk of …

Palmatine is a naturally occurring isoquinoline alkaloid that has been reported to display
neuroprotective effects against amyloid‐β‐(Aβ‐) induced neurotoxicity. However, the …

Caffeine is a naturally occurring alkaloid found in various plants. It acts as a stimulant,
antioxidant, anti-inflammatory, and even an aid in pain management, and is found in several …

Methylxanthines (MTX) are purine derived xanthine derivatives. Whereas naturally occurring
methylxanthines like caffeine, theophylline or theobromine are widely consumed in food …

Alzheimer's disease (AD) is the most common type of dementia leading to progressive
memory loss and cognitive impairment. Considering that pharmacological treatment options …

The accumulation of amyloid β-protein (Aβ) is one of the major pathological hallmarks of
Alzheimer's disease. Insulin-degrading enzyme (IDE), a zinc-metalloprotease, is a key …

Alzheimer's disease (AD) is a widespread neurodegenerative pathology responsible for
about 70% of all cases of dementia. Adenosine is an endogenous nucleoside that affects …

Scope The consumption of green tea is considered to be associated with a lower incidence
of neurodegenerative diseases. In the present study, it is investigated the role of amyloid …