Throughout its 40-year history, the field of gene therapy has been marked by many
transitions. It has seen great strides in combating human disease, has given hope to patients …

The COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) has led to an unprecedented effort toward the development of an effective …

Since long before the first approval of gene therapy for retinal disease, ocular gene therapy
has captured the hopes of patients, clinicians, and scientists alike. Indeed, the retina …

Recombinant vectors based on human adenovirus serotype 5 (HAdV-5) have been
extensively studied in preclinical models and clinical trials over the past two decades …

Background Antitumor vaccines targeting tumor-associated antigens (TAAs) can generate
antitumor immune response. A novel vaccine platform using adenovirus 5 (Ad5) vectors [E1 …

Therapeutic cancer vaccines have the potential of being integrated in the therapy of
numerous cancer types and stages. The wide spectrum of vaccine platforms and vaccine …

Abstract First-generation, E1-deleted adenovirus subtype 5 (Ad5)-based vectors, although
promising platforms for use as cancer vaccines, are impeded in activity by naturally …

Gene therapy with viral vectors has significantly advanced in the past few decades, with
adenovirus being one of the most commonly employed vectors for cancer gene therapy …

Adenovirus (Ad)-based vectors offer several benefits showing their potential for use in a
variety of vaccine applications. Recombinant Ad-based vaccines possess potent …

Since the development of the first vaccine against smallpox over two centuries ago,
vaccination strategies have been at the forefront of significantly impacting the incidences of …