Exploring host–pathogen interactions in the Dictyostelium discoideum–Mycobacterium marinum infection model of tuberculosis

S Guallar-Garrido, T Soldati - Disease Models & …, 2024 - journals.biologists.com
Mycobacterium tuberculosis is a pathogenic mycobacterium that causes tuberculosis.
Tuberculosis is a significant global health concern that poses numerous clinical challenges …

Emerging technologies and infection models in cellular microbiology

AT López-Jiménez, S Mostowy - Nature communications, 2021 - nature.com
The field of cellular microbiology, rooted in the co-evolution of microbes and their hosts,
studies intracellular pathogens and their manipulation of host cell machinery. In this review …

A TRAF-like E3 ubiquitin ligase TrafE coordinates ESCRT and autophagy in endolysosomal damage response and cell-autonomous immunity to Mycobacterium …

L Raykov, M Mottet, J Nitschke, T Soldati - Elife, 2023 - elifesciences.org
Cells are perpetually challenged by pathogens, protein aggregates or chemicals, that
induce plasma membrane or endolysosomal compartments damage. This severe stress is …

Mycobacterium bovis uses the ESX-1 Type VII secretion system to escape predation by the soil-dwelling amoeba Dictyostelium discoideum

RE Butler, AA Smith, TA Mendum, A Chandran… - The ISME …, 2020 - academic.oup.com
Mycobacterium bovis is the causative agent of bovine tuberculosis and the predominant
cause of zoonotic tuberculosis in people. Bovine tuberculosis occurs in farmed cattle but …

Novel Single-Cell and High-Throughput Microscopy Techniques to Monitor Dictyostelium discoideumMycobacterium marinum Infection Dynamics

M Mottet, C Bosmani, N Hanna, J Nitschke… - Mycobacteria …, 2021 - Springer
Abstract The Dictyostelium discoideum–Mycobacterium marinum host–pathogen system is a
well-established and powerful alternative model system to study mycobacterial infections. In …

The Dictyostelium discoideum E3 ubiquitin ligase TrafE coordinates endolysosomal damage response and cell-autonomous immunity to Mycobacterium marinum

L Raykov, M Mottet, J Nitschke, T Soldati - BioRxiv, 2021 - biorxiv.org
Cells are perpetually challenged by pathogens, protein aggregates or chemicals, that
induce plasma membrane or endolysosomal compartments damage. Endolysosomal …

Proteomic characterization of the Mycobacterium marinum-containing vacuole in Dictyostelium discoideum

A Guého, C Bosmani, J Nitschke, T Soldati - bioRxiv, 2019 - biorxiv.org
Mycobacterium tuberculosis, the causative agent of tuberculosis, is able to manipulate the
phagosome compartment in which it resides in order to establish a permissive replicative …

A brief historical and evolutionary perspective on the origin of cellular microbiology research

T Soldati, E Cardenal‐Muñoz - Cellular microbiology, 2019 - Wiley Online Library
Integrated with both a historical perspective and an evolutionary angle, this opinion article
presents a brief and personal view of the emergence of cellular microbiology research. From …

Disruption of vacuolin microdomains in the host Dictyostelium discoideum increases resistance to Mycobacterium marinum-induced membrane damage and …

C Bosmani, A Perret, F Leuba, A Guého, N Hanna… - bioRxiv, 2021 - biorxiv.org
Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis, manipulates the host
phagosome maturation pathway to replicate intracellularly. Mycobacterium marinum, a …