The traditional view that proteins possess absolute functional specificity and a single, fixed
structure conflicts with their marked ability to adapt and evolve new functions and structures …

The study of molecular evolution at the level of protein-coding genes often entails comparing
large datasets of sequences to infer their evolutionary relationships. Despite the importance …

We present a prototype of a new structural classification of proteins, SCOP2 (http://scop2.
mrc-lmb. cam. ac. uk/), that we have developed recently. SCOP2 is a successor to the …

Abstract The Structural Classification of Proteins (SCOP) database is a comprehensive
ordering of all proteins of known structure, according to their evolutionary and structural …

The seemingly limitless diversity of proteins in nature arose from only a few thousand
domain prototypes, but the origin of these themselves has remained unclear. We are …

Most of the proteins in a cell assemble into complexes to carry out their function. It is
therefore crucial to understand the physicochemical properties as well as the evolution of …

NusG homologs regulate transcription and coupled processes in all living organisms. The
Escherichia coli (E. coli) two-domain paralogs NusG and RfaH have conformationally …

Protein metamorphoses facilitated by dimerization.(Left) The structure of alternatively folded
parts (blue and red) of one Mad2 conformer (gray) is additionally stabilized by the …

How do proteins evolve? How do changes in sequence mediate changes in protein
structure, and in turn in function? This question has multiple angles, ranging from …

High-throughput genomic sequencing has focused attention on understanding differences
between species and between individuals. When this genetic variation affects protein …