Recent advances and discoveries in the mechanisms and functions of CAR T cells
This Review discusses the major advances and changes made over the past 3 years to our
understanding of chimeric antigen receptor (CAR) T cell efficacy and safety. Recently, the …
understanding of chimeric antigen receptor (CAR) T cell efficacy and safety. Recently, the …
Co-stimulatory receptor signaling in CAR-T cells
MM Honikel, SH Olejniczak - Biomolecules, 2022 - mdpi.com
T cell engineering strategies have emerged as successful immunotherapeutic approaches
for the treatment of human cancer. Chimeric Antigen Receptor T (CAR-T) cell therapy …
for the treatment of human cancer. Chimeric Antigen Receptor T (CAR-T) cell therapy …
Harnessing CD3 diversity to optimize CAR T cells
RMH Velasco Cárdenas, SM Brandl, AV Meléndez… - Nature …, 2023 - nature.com
Abstract Current US Food and Drug Administration-approved chimeric antigen receptor
(CAR) T cells harbor the T cell receptor (TCR)-derived ζ chain as an intracellular activation …
(CAR) T cells harbor the T cell receptor (TCR)-derived ζ chain as an intracellular activation …
Demethylating therapy increases anti-CD123 CAR T cell cytotoxicity against acute myeloid leukemia
N El Khawanky, A Hughes, W Yu, R Myburgh… - Nature …, 2021 - nature.com
Successful treatment of acute myeloid leukemia (AML) with chimeric antigen receptor (CAR)
T cells is hampered by toxicity on normal hematopoietic progenitor cells and low CAR T cell …
T cells is hampered by toxicity on normal hematopoietic progenitor cells and low CAR T cell …
Mutation-specific CAR T cells as precision therapy for IGLV3-21R110 expressing high-risk chronic lymphocytic leukemia
F Märkl, C Schultheiß, M Ali, SS Chen… - Nature …, 2024 - nature.com
The concept of precision cell therapy targeting tumor-specific mutations is appealing but
requires surface-exposed neoepitopes, which is a rarity in cancer. B cell receptors (BCR) of …
requires surface-exposed neoepitopes, which is a rarity in cancer. B cell receptors (BCR) of …
Screening for CD19-specific chimaeric antigen receptors with enhanced signalling via a barcoded library of intracellular domains
The immunostimulatory intracellular domains (ICDs) of chimaeric antigen receptors (CARs)
are essential for converting antigen recognition into antitumoural function. Although there …
are essential for converting antigen recognition into antitumoural function. Although there …
Self-programmed dynamics of T cell receptor condensation
A common event upon receptor–ligand engagement is the formation of receptor clusters on
the cell surface, in which signaling molecules are specifically recruited or excluded to form …
the cell surface, in which signaling molecules are specifically recruited or excluded to form …
Comparative analysis of TCR and CAR signaling informs CAR designs with superior antigen sensitivity and in vivo function
Chimeric antigen receptor (CAR)–modified T cell therapy is effective in treating lymphomas,
leukemias, and multiple myeloma in which the tumor cells express high amounts of target …
leukemias, and multiple myeloma in which the tumor cells express high amounts of target …
[HTML][HTML] Tuned activation of MSLN-CAR T cells induces superior antitumor responses in ovarian cancer models
E Schoutrop, T Poiret, I El-Serafi, Y Zhao… - … for immunotherapy of …, 2023 - ncbi.nlm.nih.gov
Background Limited persistence of functional CAR T cells in the immunosuppressive solid
tumor microenvironment remains a major hurdle in the successful translation of CAR T cell …
tumor microenvironment remains a major hurdle in the successful translation of CAR T cell …
Comparing CAR and TCR engineered T cell performance as a function of tumor cell exposure
TLA Wachsmann, AK Wouters, DFG Remst… - …, 2022 - Taylor & Francis
Chimeric antigen receptor (CAR) T cell therapies have resulted in profound clinical
responses in the treatment of CD19-positive hematological malignancies, but a significant …
responses in the treatment of CD19-positive hematological malignancies, but a significant …