Base excision repair (BER) has evolved to preserve the integrity of DNA following cellular
oxidative stress and in response to exogenous insults. The pathway is a coordinated …

Base excision repair (BER) corrects forms of oxidative, deamination, alkylation, and abasic
single-base damage that appear to have minimal effects on the helix. Since its discovery in …

Hepatocellular carcinoma (HCC) is one of the most lethal malignant tumours worldwide. The
mortality-to-incidence ratio is up to 91.6% in many countries, representing the third leading …

Hepatocellular carcinoma (HCC) is one of the most prevalent and lethal cancers worldwide
and lacks effective treatment. Herein, we found that the antifungal Natamycin (NAT) exhibits …

Abstract Background Prostate cancer (PCa) is usually considered as cold tumor. Malignancy
is associated with cell mechanic changes that contribute to extensive cell deformation …

Most of the neurodegenerative diseases and aging are associated with reactive oxygen
species (ROS) or other intracellular damaging agents that challenge the genome integrity of …

Oxidative and alkylating DNA damage occurs under normal physiological conditions and
exogenous exposure to DNA damaging agents. To counteract DNA base damage, cells …

Streptomyces gilvosporeus F607 produces large amounts of natamycin in a process
regulated by multiple networks, including two-component systems (TCSs). The macR and …

The mechanism of regulation of natamycin biosynthesis by Streptomyces in response to
oxidative stress is unclear. Here, we first show cholesterol oxidase SgnE, which catalyzes …

Esophageal mucosa undergoes mild, moderate, severe dysplasia, and other precancerous
lesions and eventually develops into carcinoma in situ, and understanding the …