The HIV-1 nucleocapsid protein (NC) is a nucleic acid chaperone, which remodels nucleic
acid structures so that the most thermodynamically stable conformations are formed. This …

The discovery of designer nucleases has made genome editing much more efficient than
before. The designer nucleases have been widely used for mechanistic studies, animal …

The clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-
associated (Cas) system discovered using bacteria has been repurposed for genome …

One salient feature of reverse transcription in retroviruses, notably in the human
immunodeficiency virus type 1, is that it requires the homologous nucleocapsid (NC) protein …

Background Interferon induced transmembrane proteins 1, 2 and 3 (IFITMs) belong to a
family of highly related antiviral factors that have been shown to interfere with a large …

The role of nucleocapsid protein (NC) in the early steps of retroviral replication appears
largely that of a facilitator for reverse transcription and integration. Using a wide variety of …

Assembly of the Gag polyprotein into new viral particles in infected cells is a crucial step in
the retroviral replication cycle. Currently, little is known about the onset of assembly in the …

HIV-1 nucleocapsid protein (NC) is a small basic protein generated by the cleavage of the
Gag structural polyprotein precusor by the viral protease during virus assembly in the …

Assembly and release of human immunodeficiency virus type 1 (HIV-1) particles is mediated
by the viral Gag polyprotein precursor. Gag is synthesized in the cytosol and rapidly …

Virus particle formation of HIV-1 is a multistep process driven by a viral structural protein,
Gag. This process takes place at the plasma membrane in most cell types. However, the …