Nexus between in silico and in vivo models to enhance clinical translation of nanomedicine

FM Kashkooli, M Soltani, M Souri, C Meaney… - Nano Today, 2021 - Elsevier
In cancer, one of the main barriers to effective chemotherapy is inefficient drug delivery. The
delivery of drugs to solid tumors involves various biochemical, biophysical, and mechanical …

[HTML][HTML] Peptide ligand-mediated targeted drug delivery of nanomedicines

Z Jiang, J Guan, J Qian, C Zhan - Biomaterials science, 2019 - pubs.rsc.org
Targeted drug delivery is emerging as a promising strategy to achieve better clinical
outcomes. Actively targeted drug delivery that utilizes overexpressed receptors or antigens …

Anti-CD24 antibody–nitric oxide conjugate selectively and potently suppresses hepatic carcinoma

F Sun, Y Wang, X Luo, Z Ma, Y Xu, X Zhang, T Lv… - Cancer research, 2019 - AACR
Nitric oxide (NO) has a wide range of potential applications in tumor therapy. However, a
targeted delivery system for NO donors has remained elusive, creating a bottleneck that …

Chemical diversification of simple synthetic antibodies

M Islam, HP Kehoe, JB Lissoos, M Huang… - ACS chemical …, 2021 - ACS Publications
Antibodies possess properties that make them valuable as therapeutics, diagnostics, and
basic research tools. However, antibody chemical reactivity and covalent antigen binding …

Mechanisms of action of the new antibodies in use in multiple myeloma

A Romano, P Storti, V Marchica, G Scandura… - Frontiers in …, 2021 - frontiersin.org
Monoclonal antibodies (mAbs) directed against antigen-specific of multiple myeloma (MM)
cells have Fc-dependent immune effector mechanisms, such as complement-dependent …

Transforming nanobodies into high-precision tools for protein function analysis

J Gettemans, B De Dobbelaer - American Journal of …, 2021 - journals.physiology.org
Single-domain antibodies, derived from camelid heavy antibodies (nanobodies) or shark
variable new antigen receptors, have attracted increasing attention in recent years due to …

[HTML][HTML] Onco-Nefrología: cáncer, quimioterapia y riñón

ALM De Francisco, M Macía, F Alonso, P García… - Nefrología, 2019 - Elsevier
La enfermedad renal crónica (ERC), el cáncer y las enfermedades hematológicas
comparten áreas de influencia recíproca. El cáncer puede afectar al riñón bien como …

Clinical application of immunogenic cell death inducers in cancer immunotherapy: turning cold tumors hot

Y Han, X Tian, J Zhai, Z Zhang - Frontiers in Cell and Developmental …, 2024 - frontiersin.org
Immunotherapy has emerged as a promising cancer treatment option in recent years. In
immune “hot” tumors, characterized by abundant immune cell infiltration, immunotherapy …

[HTML][HTML] Onco-Nephrology: Cancer, chemotherapy and kidney

ALM de Francisco, M Macía, F Alonso, P García… - Nefrología (English …, 2019 - Elsevier
Chronic kidney disease (CKD), cancer and hematological diseases share areas of
reciprocal influence. Cancer can affect the kidney either as glomerular lesions or as a result …

Considerations for setting occupational exposure limits for novel pharmaceutical modalities

JC Graham, J Hillegass, G Schulze - Regulatory Toxicology and …, 2020 - Elsevier
In order to develop new and effective medicines, pharmaceutical companies must be
modality agnostic. As science reveals an enhanced understanding of biological processes …