Nexus between in silico and in vivo models to enhance clinical translation of nanomedicine
In cancer, one of the main barriers to effective chemotherapy is inefficient drug delivery. The
delivery of drugs to solid tumors involves various biochemical, biophysical, and mechanical …
delivery of drugs to solid tumors involves various biochemical, biophysical, and mechanical …
[HTML][HTML] Peptide ligand-mediated targeted drug delivery of nanomedicines
Z Jiang, J Guan, J Qian, C Zhan - Biomaterials science, 2019 - pubs.rsc.org
Targeted drug delivery is emerging as a promising strategy to achieve better clinical
outcomes. Actively targeted drug delivery that utilizes overexpressed receptors or antigens …
outcomes. Actively targeted drug delivery that utilizes overexpressed receptors or antigens …
Anti-CD24 antibody–nitric oxide conjugate selectively and potently suppresses hepatic carcinoma
F Sun, Y Wang, X Luo, Z Ma, Y Xu, X Zhang, T Lv… - Cancer research, 2019 - AACR
Nitric oxide (NO) has a wide range of potential applications in tumor therapy. However, a
targeted delivery system for NO donors has remained elusive, creating a bottleneck that …
targeted delivery system for NO donors has remained elusive, creating a bottleneck that …
Chemical diversification of simple synthetic antibodies
Antibodies possess properties that make them valuable as therapeutics, diagnostics, and
basic research tools. However, antibody chemical reactivity and covalent antigen binding …
basic research tools. However, antibody chemical reactivity and covalent antigen binding …
Mechanisms of action of the new antibodies in use in multiple myeloma
A Romano, P Storti, V Marchica, G Scandura… - Frontiers in …, 2021 - frontiersin.org
Monoclonal antibodies (mAbs) directed against antigen-specific of multiple myeloma (MM)
cells have Fc-dependent immune effector mechanisms, such as complement-dependent …
cells have Fc-dependent immune effector mechanisms, such as complement-dependent …
Transforming nanobodies into high-precision tools for protein function analysis
J Gettemans, B De Dobbelaer - American Journal of …, 2021 - journals.physiology.org
Single-domain antibodies, derived from camelid heavy antibodies (nanobodies) or shark
variable new antigen receptors, have attracted increasing attention in recent years due to …
variable new antigen receptors, have attracted increasing attention in recent years due to …
[HTML][HTML] Onco-Nefrología: cáncer, quimioterapia y riñón
ALM De Francisco, M Macía, F Alonso, P García… - Nefrología, 2019 - Elsevier
La enfermedad renal crónica (ERC), el cáncer y las enfermedades hematológicas
comparten áreas de influencia recíproca. El cáncer puede afectar al riñón bien como …
comparten áreas de influencia recíproca. El cáncer puede afectar al riñón bien como …
Clinical application of immunogenic cell death inducers in cancer immunotherapy: turning cold tumors hot
Y Han, X Tian, J Zhai, Z Zhang - Frontiers in Cell and Developmental …, 2024 - frontiersin.org
Immunotherapy has emerged as a promising cancer treatment option in recent years. In
immune “hot” tumors, characterized by abundant immune cell infiltration, immunotherapy …
immune “hot” tumors, characterized by abundant immune cell infiltration, immunotherapy …
[HTML][HTML] Onco-Nephrology: Cancer, chemotherapy and kidney
ALM de Francisco, M Macía, F Alonso, P García… - Nefrología (English …, 2019 - Elsevier
Chronic kidney disease (CKD), cancer and hematological diseases share areas of
reciprocal influence. Cancer can affect the kidney either as glomerular lesions or as a result …
reciprocal influence. Cancer can affect the kidney either as glomerular lesions or as a result …
Considerations for setting occupational exposure limits for novel pharmaceutical modalities
JC Graham, J Hillegass, G Schulze - Regulatory Toxicology and …, 2020 - Elsevier
In order to develop new and effective medicines, pharmaceutical companies must be
modality agnostic. As science reveals an enhanced understanding of biological processes …
modality agnostic. As science reveals an enhanced understanding of biological processes …