The capacity for human exercise performance can be enhanced with prolonged exercise
training, whether it is endurance-or strength-based. The ability to adapt through exercise …

Insulin resistance plays a key role in the development of type 2 diabetes. It arises from a
combination of genetic predisposition and environmental and lifestyle factors including lack …

Skeletal muscle plays a fundamental role in mobility, disease prevention, and quality of life.
Skeletal muscle mass is, in part, determined by the rates of protein synthesis, and …

A predisposing factor for development of the hyperglycaemic state of gestational diabetes
mellitus (GDM) is obesity. We previously showed that increasing maternal obesity is …

Concurrent training, a combination of endurance (EE) and resistance exercise (RE)
performed in succession, may compromise the muscle hypertrophic adaptations induced by …

A recent study demonstrated that heat stress induces mitochondrial biogenesis in C2C12
myotubes, thereby implying that heat stress may be an effective treatment to enhance …

Key points Previous studies have shown that endurance exercise increases myofibrillar
(MyoPS) and mitochondrial (MitoPS) protein synthesis in skeletal muscle. The mechanistic …

The metabolic stress placed on skeletal muscle by aerobic exercise promotes acute and
long-term health benefits in part through changes in gene expression. However, the …

Working muscle conserves adenosine triphosphate (ATP) for muscle contraction by
attenuating protein synthesis through several different pathways. Regulated in development …

Insulin signaling plays a key role in glucose uptake, glycogen synthesis, and protein and
lipid synthesis. In insulin-resistant states like obesity and type 2 diabetes mellitus, these …