Over the past 20 years, and particularly in the last decade, significant developmental
milestones have driven basic, translational, and clinical advances in the field of stem cell …

The discovery of somatic cell nuclear transfer proved that somatic cells can carry the same
genetic code as the zygote, and that activating parts of this code are sufficient to reprogram …

The past 10 years have seen great advances in our ability to manipulate cell fate, including
the induction of pluripotency in vitro to generate induced pluripotent stem cells (iPSCs). This …

Somatic cell reprogramming provides insight into basic principles of cell fate determination,
which remain poorly understood. Here we show that the transcription factor Glis1 induces …

Recent progresses in the field of Induced Pluripotent Stem Cells (iPSCs) have opened up
many gateways for the research in therapeutics. iPSCs are the cells which are …

Factor-induced reprogramming of somatic cells into induced pluripotent stem cells (iPSCs) is
inefficient, complicating mechanistic studies. Here, we examined defined intermediate cell …

The transcriptional coactivator peroxisome proliferator-activated receptor-gamma coactivator-
1α (PGC-1α) regulates metabolic genes in skeletal muscle and contributes to the response …

Regulatory role of Sirtuin 1 (SIRT1), one of the most extensively studied members of its kind
in histone deacetylase family in governing multiple cellular fates, is predominantly linked to …

The field of stem-cell biology has been catapulted forward by the startling development of
reprogramming technology. The ability to restore pluripotency to somatic cells through the …

The generation of large numbers of functional human hepatocytes for cell-based
approaches to liver disease is an important and unmet goal. Direct reprogramming of …