Comprehensive review in current developments of benzimidazole‐based medicinal chemistry
The properties of benzimidazole and its derivatives have been studied over more than one
hundred years. Benzimidazole derivatives are useful intermediates/subunits for the …
hundred years. Benzimidazole derivatives are useful intermediates/subunits for the …
1, 2, 3‐Triazole hybrids with anti‐HIV‐1 activity
LS Feng, MJ Zheng, F Zhao, D Liu - Archiv der Pharmazie, 2021 - Wiley Online Library
The human immunodeficiency virus type 1 (HIV‐1) is the major etiological agent responsible
for the acquired immunodeficiency syndrome (AIDS), which is a serious infectious disease …
for the acquired immunodeficiency syndrome (AIDS), which is a serious infectious disease …
Bacterial GCN5-Related N-Acetyltransferases: From Resistance to Regulation
L Favrot, JS Blanchard, O Vergnolle - Biochemistry, 2016 - ACS Publications
The GCN5-related N-acetyltransferases family (GNAT) is an important family of proteins that
includes more than 100000 members among eukaryotes and prokaryotes. Acetylation …
includes more than 100000 members among eukaryotes and prokaryotes. Acetylation …
Small molecules targeting viral RNA
T Hermann - Wiley Interdisciplinary Reviews: RNA, 2016 - Wiley Online Library
Highly conserved noncoding RNA (ncRNA) elements in viral genomes and transcripts offer
new opportunities to expand the repertoire of drug targets for the development of …
new opportunities to expand the repertoire of drug targets for the development of …
Frameworks for targeting RNA with small molecules
AU Juru, AE Hargrove - Journal of Biological Chemistry, 2021 - ASBMB
Since the characterization of mRNA in 1961, our understanding of the roles of RNA
molecules has significantly grown. Beyond serving as a link between DNA and proteins …
molecules has significantly grown. Beyond serving as a link between DNA and proteins …
Amiloride as a new RNA-binding scaffold with activity against HIV-1 TAR
Diversification of RNA-targeted scaffolds offers great promise in the search for selective
ligands of therapeutically relevant RNA such as HIV-1 TAR. We herein report the …
ligands of therapeutically relevant RNA such as HIV-1 TAR. We herein report the …
Functionalized benzimidazole scaffolds: privileged heterocycle for drug design in therapeutic medicine
Benzimidazole derivatives are crucial structural scaffolds found in diverse libraries of
biologically active compounds which are therapeutically useful agents in drug discovery and …
biologically active compounds which are therapeutically useful agents in drug discovery and …
Syntheses, characterization, and catalytic potential of novel vanadium and molybdenum Schiff base complexes for the preparation of benzimidazoles, benzoxazoles …
H Kargar, K Kargar, M Fallah-Mehrjardi… - Monatshefte für Chemie …, 2021 - Springer
A new ONO-tridentate Schiff base ligand (H2L) derived from 3-methoxysalicylaldehyde and
nicotinic hydrazide was synthesized and characterized by elemental analysis, FT-IR, 1H …
nicotinic hydrazide was synthesized and characterized by elemental analysis, FT-IR, 1H …
Fluorescent peptide displacement as a general assay for screening small molecule libraries against RNA
NN Patwardhan, Z Cai, CN Newson… - Organic & biomolecular …, 2019 - pubs.rsc.org
A prominent hurdle in developing small molecule probes against RNA is the relative scarcity
of general screening methods. In this study, we demonstrate the application of a fluorescent …
of general screening methods. In this study, we demonstrate the application of a fluorescent …
HIV-1 frameshift RNA-targeted triazoles inhibit propagation of replication-competent and multi-drug-resistant HIV in human cells
TA Hilimire, JM Chamberlain, V Anokhina… - ACS Chemical …, 2017 - ACS Publications
The HIV-1 frameshift-stimulating (FSS) RNA, a regulatory RNA of critical importance in the
virus' life cycle, has been posited as a novel target for anti-HIV drug development. We report …
virus' life cycle, has been posited as a novel target for anti-HIV drug development. We report …