Purines and their derivatives, most notably adenosine and ATP, are the key molecules
controlling intracellular energy homoeostasis and nucleotide synthesis. Besides, these …

Neuroinflammation is a multifaceted physiological and pathophysiological response of the
brain to injury and disease. Given imaging findings of 18 kDa translocator protein (TSPO) …

Microglia are the resident macrophages of the central nervous system. They play key roles
in brain development, and physiology during life and aging. Equipped with a variety of …

Alzheimer's disease (AD) is the most common form of dementia worldwide, with a complex,
poorly understood pathogenesis. Cerebral atrophy, amyloid-β (Aβ) plaques, and …

Under physiological conditions, adenosine triphosphate (ATP) is present at low levels in the
extracellular milieu, being massively released by stressed or dying cells. Once outside the …

Alzheimer's disease (AD) is one of the most common neurodegenerative diseases, and it is
characterised by progressive deterioration in cognitive and memory abilities, which can …

Microglial cells are the resident macrophages in the central nervous system. These cells of
mesodermal/mesenchymal origin migrate into all regions of the central nervous system …

Alzheimer's disease (AD) is one of the most common types of age-related dementia
worldwide. In addition to extracellular amyloid plaques and intracellular neurofibrillary …

The P2X7 receptor is a cation channel activated by high concentrations of adenosine
triphosphate (ATP). Upon long-term activation, it complexes with membrane proteins forming …

Microglial activation is a distinguished attribute in many neurodegenerative diseases of
aging. Compelling evidence suggests that neuroinflammation stimulated by microglia, the …