Obesity and its comorbidities, including type 2 diabetes and cardiovascular disease, are
straining our healthcare system, necessitating the development of novel strategies for weight …

Atherosclerosis is a complex disease process that affects very specific sites of the
vasculature. It is recognized that hemodynamic forces are largely responsible for dictating …

The formation of atherosclerotic plaques in the large and medium sized arteries is classically
driven by systemic factors, such as elevated cholesterol and blood pressure. However, work …

Foam cell formation and further accumulation in the subendothelial space of the vascular
wall is a hallmark of atherosclerotic lesions. Targeting foam cell formation in the …

Aims As the inflammatory enzyme myeloperoxidase (MPO) is abundant in ruptured human
atherosclerotic plaques, we aimed to investigate the role of MPO as a potential diagnostic …

Vascular smooth muscle cell (SMC) phenotypic modulation plays a key role in
atherosclerosis and is classically defined as a switch from a 'contractile'phenotype to a …

INTRODUCTION: Cardiovascular disease, the leading cause of death in much of the
modern world, is the common symptomatic end stage of a number of distinct diseases and …

Atherosclerotic plaque forms in regions of the vasculature exposed to disturbed flow. NF-κB
activation by fluid flow, leading to expression of target genes such as E-selectin, ICAM-1 …

The accumulation of low-density lipoproteins (LDL) in the arterial wall plays a pivotal role in
the initiation and pathogenesis of atherosclerosis. Conversely, the removal of cholesterol …

Common forms of atherosclerosis involve multiple genetic and environmental factors. While
human genome-wide association studies have identified numerous loci contributing to …