The immune system and cancer have a complex relationship with the immune system
playing a dual role in tumor development. The effector cells of the immune system can …

The shuttling of leukocytes between the bloodstream and interstitial tissues involves different
locomotion strategies that are governed by locally presented soluble and cell-bound signals …

The relevance of extracellular magnesium in cellular immunity remains largely unknown.
Here, we show that the co-stimulatory cell-surface molecule LFA-1 requires magnesium to …

The human immune system is composed of a distributed network of cells circulating
throughout the body, which must dynamically form physical associations and communicate …

The activation of leukocyte integrins through diverse receptors results in transformation of
the integrin from a bent, resting form to an extended conformation, which has at least two …

Integrins are the principal cell adhesion receptors that mediate leukocyte migration and
activation in the immune system. These receptors signal bidirectionally through the plasma …

Cytokine-based immunotherapy is a promising field in the cancer treatment, since cytokines,
as proteins of the immune system, are able to modulate the host immune response toward …

A successful immune response depends on the capacity of immune cells to travel from one
location in the body to another–these cells are rapid migrators, travelling at speeds of …

The ability of cells to attach to each other and to the extracellular matrix is of pivotal
significance for the formation of functional organs and for the distribution of cells in the body …

Endothelial chemokines are instrumental for integrin-mediated lymphocyte adhesion and
transendothelial migration (TEM). By dissecting how chemokines trigger lymphocyte …