Emerging targets in type 2 diabetes and diabetic complications
S Demir, PP Nawroth, S Herzig… - Advanced …, 2021 - Wiley Online Library
Type 2 diabetes is a metabolic, chronic disorder characterized by insulin resistance and
elevated blood glucose levels. Although a large drug portfolio exists to keep the blood …
elevated blood glucose levels. Although a large drug portfolio exists to keep the blood …
[HTML][HTML] The aftermath of the interplay between the endoplasmic reticulum stress response and redox signaling
KR Bhattarai, TA Riaz, HR Kim, HJ Chae - Experimental & molecular …, 2021 - nature.com
The endoplasmic reticulum (ER) is an essential organelle of eukaryotic cells. Its main
functions include protein synthesis, proper protein folding, protein modification, and the …
functions include protein synthesis, proper protein folding, protein modification, and the …
[HTML][HTML] Crosstalk between ER stress, autophagy and inflammation
S Chipurupalli, U Samavedam, N Robinson - Frontiers in Medicine, 2021 - frontiersin.org
The endoplasmic reticulum (ER) is not only responsible for protein synthesis and folding but
also plays a critical role in sensing cellular stress and maintaining cellular homeostasis …
also plays a critical role in sensing cellular stress and maintaining cellular homeostasis …
Chinese herbal medicines: The modulator of nonalcoholic fatty liver disease targeting oxidative stress
P Gong, H Long, Y Guo, Z Wang, W Yao, J Wang… - Journal of …, 2024 - Elsevier
Ethnopharmacological relevance Plants are a natural treasure trove; their secondary
metabolites participate in several pharmacological processes, making them a crucial …
metabolites participate in several pharmacological processes, making them a crucial …
[HTML][HTML] Antioxidant role of kaempferol in prevention of hepatocellular carcinoma
Reactive oxygen species (ROS) are noxious to cells because their increased level interacts
with the body's defense mechanism. These species also cause mutations and uncontrolled …
with the body's defense mechanism. These species also cause mutations and uncontrolled …
Calcium signaling and endoplasmic reticulum stress
J Groenendyk, LB Agellon, M Michalak - International review of cell and …, 2021 - Elsevier
Cellular homeostasis is essential for healthy functioning of cells and tissues as well as
proper organ development and maintenance. A disruption in cellular homeostasis triggers …
proper organ development and maintenance. A disruption in cellular homeostasis triggers …
[HTML][HTML] Drug resistance and endoplasmic reticulum stress in hepatocellular carcinoma
J Khaled, M Kopsida, H Lennernäs, F Heindryckx - Cells, 2022 - mdpi.com
Hepatocellular carcinoma (HCC) is one of the most common and deadly cancers worldwide.
It is usually diagnosed in an advanced stage and is characterized by a high intrinsic drug …
It is usually diagnosed in an advanced stage and is characterized by a high intrinsic drug …
Roflumilast prevents ischemic stroke-induced neuronal damage by restricting GSK3β-mediated oxidative stress and IRE1α/TRAF2/JNK pathway
B Xu, J Xu, N Cai, M Li, L Liu, Y Qin, X Li… - Free Radical Biology and …, 2021 - Elsevier
Abstract Inhibition of phosphodiesterase 4 (PDE4) protects against neuronal apoptosis
induced by cerebral ischemia. However, the exact mechanisms responsible for the …
induced by cerebral ischemia. However, the exact mechanisms responsible for the …
Medical gas therapy for tissue, organ, and CNS protection: a systematic review of effects, mechanisms, and challenges
RD Zafonte, L Wang, CA Arbelaez… - Advanced …, 2022 - Wiley Online Library
Gaseous molecules have been increasingly explored for therapeutic development. Here,
following an analytical background introduction, a systematic review of medical gas …
following an analytical background introduction, a systematic review of medical gas …
Endoplasmic reticulum stress and oxidative stress in inflammatory diseases
Y Tang, X Zhou, T Cao, E Chen, Y Li, W Lei… - DNA and Cell …, 2022 - liebertpub.com
Endoplasmic reticulum (ER) stress and oxidative stress (OS) are often related states in cells
as part of normal physiology but more frequently manifested in the pathophysiology of many …
as part of normal physiology but more frequently manifested in the pathophysiology of many …