Aberrant epigenetics is a hallmark of cancer, and endocrine-related tumors are no
exception. Recent research has been identifying an ever-growing number of epigenetic …

Cellular pathways are numerous and are highly integrated in function in the control of
cellular systems. They collectively regulate cell division, proliferation, survival and apoptosis …

Background: Promoter methylation of tumour suppressor genes (TSGs) CDKN2A, CDKN2B
and CDH13 has been reported in ovarian cancer. However, the clinicopathological …

Silencing of tumor suppressor and tumor-related genes by promoter hypermethylation is one
of the major events in ovarian carcinogenesis. In this study, we analyzed aberrant promoter …

Background Ovarian cancer is the primary cause of death in women diagnosed with
gynecological malignancies worldwide. Absence of early symptoms prevents prompt …

To detect the blood genomic DNA methylation in coke oven workers and find a possible
early screening index for occupational lung cancer, 74 coke oven workers as the exposed …

Ovarian cancer is the fourth most common cancer in women worldwide. It is very
heterogeneous at the clinical, histopathological and molecular levels and is caused by the …

Epigenetic alteration of P16INK4a is conventionally thought to induce the initiation of
carcinoma. However, the role of P16INK4a methylation in ovarian cancer still remains …

Background p16 INK4A (p16) functions as a tumor suppressor gene in various
malignancies. Aberrant p16 methylation has been proposed to be essential in ovarian …

Gankyrin is an ankyrin repeat protein known for its oncogenic effects and its up-regulation in
the early stages of almost all cases of hepatocellular carcinoma, as well as other cancers. It …