Hepatocytes form a crucially important cell layer that separates sinusoidal blood from the
canalicular bile. They have a uniquely organized polarity with a basal membrane facing liver …

Recent development of improved tools and methods to analyse tissues at the three-
dimensional level has expanded our capacity to investigate morphogenesis of foetal liver …

The hydrolysis of ATP drives virtually all of the energy-requiring processes in living cells. A
prerequisite of living cells is that the concentration of ATP needs to be maintained at …

Hepatocytes, like other epithelia, are situated at the interface between the organism's
exterior and the underlying internal milieu and organize the vectorial exchange of …

Acute on chronic liver failure (ACLF) is associated with multisystem organ failure and poor
prognosis in hospitalized patients with cirrhosis. We aimed to determine time trends in the …

The nuclear bile acid receptor farnesoid X receptor (FXR) is an important transcriptional
regulator of bile acid, lipid, and glucose metabolism. FXR is highly expressed in the liver and …

The bile salt export pump (BSEP) is the major transporter for the secretion of bile acids from
hepatocytes into bile in humans. Mutations of BSEP are associated with cholestatic liver …

The involvement of the biliary tract in the pathophysiology of liver diseases and the
increased attention paid to bile ducts in the bioconstruction of liver tissue for regenerative …

Despite significant advances in our understanding of the biology determining systemic
energy homeostasis, the treatment of obesity remains a medical challenge. Activation of …

In epithelial cells, the polarized orientation of the apical–basal axis determines the position
of the apical lumen and, thereby, the collective tubular tissue architecture. From recent …