Neuroimmunology, albeit a relatively established discipline, has recently sparked numerous
exciting findings on microglia, the resident macrophages of the central nervous system …

Contemporary studies have completely changed the view of brain immunity from envisioning
the brain as isolated and inaccessible to peripheral immune cells to an organ in close …

For decades, it was commonly accepted that the brain is secluded from peripheral immune
activity and is self-sufficient for its maintenance and repair. This simplistic perception was …

The brain is a site of relative immune privilege. Although CD4 T cells have been reported in
the central nervous system, their presence in the healthy brain remains controversial, and …

Microglia are the primary innate immune cells in the CNS. In the healthy brain, they exhibit a
unique molecular homeostatic 'signature', consisting of a specific transcriptional profile and …

Adult neurogenesis in the dentate gyrus of the hippocampus is regulated by specific
microglia groups and functionally implicated in behavioral responses to stress. However, the …

Alzheimer's disease (AD) and dementia in general are age-related diseases with multiple
contributing factors, including brain inflammation. Microglia, and specifically those …

Alzheimer's disease (AD) is a detrimental neurodegenerative disease with no effective
treatments. Due to cellular heterogeneity, defining the roles of immune cell subsets in AD …

The immune and nervous systems have unique developmental trajectories that individually
build intricate networks of cells with highly specialized functions. These two systems have …

There is significant interest in understanding inflammatory responses within the brain and
spinal cord. Inflammatory responses that are centralized within the brain and spinal cord are …