This review gives a brief account of the main processes of lens development, including
induction, morphogenesis, differentiation and growth. It describes what is known about the …

Development of the ocular anterior segment involves a series of inductive interactions
between neural ectoderm, surface ectoderm and periocular mesenchyme. The timing of …

Human congenital cataract and ocular anterior segment dysgenesis both demonstrate
extensive genetic and phenotypic heterogeneity. We identified a family where ocular …

To elucidate the regulatory mechanisms underlying lens development, we searched for
members of the large Maf family, which are expressed in the mouse lens, and found three, c …

The vertebrate lens is a tissue composed of terminally differentiated fiber cells and anterior
lens epithelial cells. The abundant, preferential expression of the soluble proteins called …

Maf is a basic domain/leucine zipper domain protein originally identified as a proto-
oncogene whose consensus target site in vitro, the T-MARE, is an extended version of an …

After the vertebrate lens is induced from head ectoderm, lens-specific genes are expressed.
Transcriptional regulation of the lens-specific αA-crystallin gene is controlled by an …

Mouse aphakia (ak) is a recessive phenotype that spontaneously occurs in the 129/Sv-SlJ
strain and is characterized by small eyes that lack a lens. We have recently identified a …

This book provides a comprehensive view of research in lens developmental biology,
emphasising technical and molecular breakthroughs. Elucidation of the mechanisms that …

A large number of mammalian transcription factors possess the evolutionary conserved
basic and leucine zipper domain (bZIP). The basic domain interacts with DNA while the …