The success of next-generation androgen receptor (AR) pathway inhibitors, such as
abiraterone acetate and enzalutamide, in treating prostate cancer has been hampered by …

Myeloid-derived suppressor cells (MDSCs) represent a heterogenous population of
immature myeloid cells capable of modulating immune responses. In the context of cancer …

Recurrent mutations at R140 and R172 in isocitrate dehydrogenase 2 (IDH2) occur in many
cancers, including∼ 12% of acute myeloid leukemia (AML). In preclinical models these …

Retinoic acid (RA), the major bioactive metabolite of retinol or vitamin A, induces a spectrum
of pleiotropic effects in cell growth and differentiation that are relevant for embryonic …

The AGC family of serine/threonine kinases (PKA, PKG, PKC) includes more than 60
members that are critical regulators of numerous cellular functions, including cell cycle and …

Hepatocyte nuclear factor 3γ (HNF3γ) is a hepatocyte nuclear factor, but its role and clinical
significance in hepatocellular carcinoma (HCC) remain unclear. Herein, we report that …

Histone deacetylases (HDACs) are considered to be among the most promising targets in
drug development for cancer therapy, and first-generation histone deacetylase inhibitors …

Acute promyelocytic leukemia (APL) is a distinct subtype of acute myeloid leukemia.
Morphologically, it is identified as the M3 subtype of acute myeloid leukemia by the French …

Defective dendritic cell (DC) function caused by abnormal differentiation of these cells is an
important mechanism of tumor escape from immune system control. Previously, we have …

The discovery of anticancer drugs is now driven by the numerous molecular alterations
identified in tumor cells over the past decade. To exploit these alterations, it is necessary to …