Myofibroblasts are activated in response to tissue injury with the primary task to repair lost or
damaged extracellular matrix. Enhanced collagen secretion and subsequent contraction …

Elements of the vertebrate skeleton are initiated as cell condensations, collectively termed
the 'membranous skeleton'whether cartilages or bones by Grüneberg (1963) …

To delineate specific developmental roles of transforming growth factor beta 1 (TGF-beta 1)
we have disrupted its cognate gene in mouse embryonic stem cells by homologous …

The scid mutation was backcrossed ten generations onto the NOD/Lt strain background,
resulting in an immunodeficient stock (NOD/LtSz-scid/scid) with multiple defects in adaptive …

Marfan syndrome is an autosomal dominant disorder of connective tissue caused by
mutations in fibrillin-1 (encoded by FBN1 in humans and Fbn1 in mice), a matrix component …

Diabetes is now the most common cause of progressive kidney failure leading to dialysis or
transplantation. The central pathological feature of diabetic nephropathy is accumulation of …

Idiopathic pulmonary fibrosis is an inexorably fatal disorder characterized by connective
tissue deposition within the terminal air spaces resulting in loss of lung function and …

Mitral valve prolapse (MVP) is a common human phenotype, yet little is known about the
pathogenesis of this condition. MVP can occur in the context of genetic syndromes, including …

Aberrant expression of transforming growth factor beta 1 (TGF-beta 1) has been implicated
in a number of disease processes, particularly those involving fibrotic and inflammatory …

We have investigated the ability of exogenous transforming growth factor-beta (TGF-beta) to
induce osteogenesis and chondrogenesis, critical events in both bone formation and …