Antibacterials play a key role in the treatment of bone infections and appropriate surgical
prophylaxis. The rate and extent of penetration of antimicrobials into bone has been …

The pharmacokinetics and pharmacodynamics of drugs are different in adult and paediatric
populations, the latter being particularly heterogeneous. These differences in …

The focus of this book is primarily on the development of pharmacokinetic and
pharmacokinetic-pharmacodynamic models. Models that are reported in the literature are …

Optimal Design for Nonlinear Response Models discusses the theory and applications of
model-based experimental design with a strong emphasis on biopharmaceutical studies …

Population kinetic analysis is the methodology used to quantify inter-subject variability in
kinetic studies. It entails the collection of (possibly sparse) data from dynamic experiments in …

We extend the methodology for designs evaluation and optimization in nonlinear mixed
effects models with an illustration of the decrease of human immunodeficiency virus viral …

Experimental design is fundamental to successful scientific investigation. Poorly designed
experiments lead to the loss of information, which is costly and potentially unethical …

The goal of this manuscript is to introduce a framework for consideration of designs for
population pharmacokinetic orpharmacokinetic–pharmacodynamic studies. A standard one …

Developing the skills or expertise to create useful population pharmacokinetic-
pharmacodynamic models can be a daunting task-the level of mathematical and statistical …

An inverse method was developed to determine the material constitutive parameters of
human articular cartilage from stress relaxation indentation tests. The cartilage was modeled …