Oxidative stress and the pathophysiology and symptom profile of schizophrenia spectrum disorders
Schizophrenia is associated with increased levels of oxidative stress, as reflected by an
increase in the concentrations of damaging reactive species and a reduction in anti-oxidant …
increase in the concentrations of damaging reactive species and a reduction in anti-oxidant …
Mitochondrial dysfunction in schizophrenia: pathways, mechanisms and implications
Mitochondria play a critical role in regulating cellular functions including bioenergetics,
calcium homeostasis, redox signalling, and apoptotic cell death. Mitochondria are also …
calcium homeostasis, redox signalling, and apoptotic cell death. Mitochondria are also …
Oxidative stress, prefrontal cortex hypomyelination and cognitive symptoms in schizophrenia
DA Maas, A Vallès, GJM Martens - Translational psychiatry, 2017 - nature.com
Schizophrenia (SZ) is a neurodevelopmental disorder with a broad symptomatology,
including cognitive symptoms that are thought to arise from the prefrontal cortex (PFC). The …
including cognitive symptoms that are thought to arise from the prefrontal cortex (PFC). The …
Mitochondria transfer in brain injury and disease
Intercellular mitochondria transfer is a novel form of cell signalling in which whole
mitochondria are transferred between cells in order to enhance cellular functions or aid in …
mitochondria are transferred between cells in order to enhance cellular functions or aid in …
[HTML][HTML] Ellagic acid, a polyphenolic compound, selectively induces ROS-mediated apoptosis in cancerous B-lymphocytes of CLL patients by directly targeting …
To investigate the effects ofellagic acid (EA) on the cytotoxicity, B-lymphocytes isolated from
CLL patients and healthy individuals. Flow cytometric assay was used to measure the …
CLL patients and healthy individuals. Flow cytometric assay was used to measure the …
Methotrexate induced mitochondrial injury and cytochrome c release in rat liver hepatocytes
A Al Maruf, PJ O'Brien, P Naserzadeh… - Drug and chemical …, 2018 - Taylor & Francis
Methotrexate (MTX) is a folic acid antagonist that is widely used to treat a variety of diseases.
One of the most serious side effects of MTX therapy is hepatotoxicity. The potential …
One of the most serious side effects of MTX therapy is hepatotoxicity. The potential …
Sex difference alters the behavioral and cognitive performance in a rat model of schizophrenia induced by sub-chronic ketamine
MA Samizadeh, ST Abdollahi-Keyvani, H Fallah… - Journal of Psychiatric …, 2024 - Elsevier
Schizophrenia is a complex neuropsychiatric disorder with positive, negative, and cognitive
symptoms. In rats, sub-chronic administration of ketamine is used for the induction of …
symptoms. In rats, sub-chronic administration of ketamine is used for the induction of …
Potential therapeutic antipsychotic effects of Naringin against ketamine-induced deficits in rats: involvement of Akt/GSK-3β and Wnt/β-catenin signaling pathways
Aim Schizophrenia is a chronic, disabling and one of the major neurological illnesses
affecting nearly 1% of the global population. Currently available antipsychotic medications …
affecting nearly 1% of the global population. Currently available antipsychotic medications …
Clozapine protects adult neural stem cells from ketamine-induced cell death in correlation with decreased apoptosis and autophagy
Adult neurogenesis, the production of newborn neurons from neural stem cells (NSCs) has
been suggested to be decreased in patients with schizophrenia. A similar finding was …
been suggested to be decreased in patients with schizophrenia. A similar finding was …
[HTML][HTML] Caffeine consumption and schizophrenia: A highlight on adenosine receptor–independent mechanisms
L Huang, B Sperlágh - Current opinion in pharmacology, 2021 - Elsevier
Schizophrenia is a common psychiatric disorder which affects approximately 1% of the
population worldwide. However, the complexity of etiology, treatment resistance and side …
population worldwide. However, the complexity of etiology, treatment resistance and side …