Oxidative stress and the pathophysiology and symptom profile of schizophrenia spectrum disorders

AJ Murray, JC Rogers, MZUH Katshu, PF Liddle… - Frontiers in …, 2021 - frontiersin.org
Schizophrenia is associated with increased levels of oxidative stress, as reflected by an
increase in the concentrations of damaging reactive species and a reduction in anti-oxidant …

Mitochondrial dysfunction in schizophrenia: pathways, mechanisms and implications

A Rajasekaran, G Venkatasubramanian, M Berk… - Neuroscience & …, 2015 - Elsevier
Mitochondria play a critical role in regulating cellular functions including bioenergetics,
calcium homeostasis, redox signalling, and apoptotic cell death. Mitochondria are also …

Oxidative stress, prefrontal cortex hypomyelination and cognitive symptoms in schizophrenia

DA Maas, A Vallès, GJM Martens - Translational psychiatry, 2017 - nature.com
Schizophrenia (SZ) is a neurodevelopmental disorder with a broad symptomatology,
including cognitive symptoms that are thought to arise from the prefrontal cortex (PFC). The …

Mitochondria transfer in brain injury and disease

LH Fairley, A Grimm, A Eckert - Cells, 2022 - mdpi.com
Intercellular mitochondria transfer is a novel form of cell signalling in which whole
mitochondria are transferred between cells in order to enhance cellular functions or aid in …

[HTML][HTML] Ellagic acid, a polyphenolic compound, selectively induces ROS-mediated apoptosis in cancerous B-lymphocytes of CLL patients by directly targeting …

A Salimi, MH Roudkenar, L Sadeghi, A Mohseni… - Redox biology, 2015 - Elsevier
To investigate the effects ofellagic acid (EA) on the cytotoxicity, B-lymphocytes isolated from
CLL patients and healthy individuals. Flow cytometric assay was used to measure the …

Methotrexate induced mitochondrial injury and cytochrome c release in rat liver hepatocytes

A Al Maruf, PJ O'Brien, P Naserzadeh… - Drug and chemical …, 2018 - Taylor & Francis
Methotrexate (MTX) is a folic acid antagonist that is widely used to treat a variety of diseases.
One of the most serious side effects of MTX therapy is hepatotoxicity. The potential …

Sex difference alters the behavioral and cognitive performance in a rat model of schizophrenia induced by sub-chronic ketamine

MA Samizadeh, ST Abdollahi-Keyvani, H Fallah… - Journal of Psychiatric …, 2024 - Elsevier
Schizophrenia is a complex neuropsychiatric disorder with positive, negative, and cognitive
symptoms. In rats, sub-chronic administration of ketamine is used for the induction of …

Potential therapeutic antipsychotic effects of Naringin against ketamine-induced deficits in rats: involvement of Akt/GSK-3β and Wnt/β-catenin signaling pathways

MY George, ET Menze, A Esmat, MG Tadros… - Life sciences, 2020 - Elsevier
Aim Schizophrenia is a chronic, disabling and one of the major neurological illnesses
affecting nearly 1% of the global population. Currently available antipsychotic medications …

Clozapine protects adult neural stem cells from ketamine-induced cell death in correlation with decreased apoptosis and autophagy

M Lundberg, S Curbo, H Bohman, I Agartz… - Bioscience …, 2020 - portlandpress.com
Adult neurogenesis, the production of newborn neurons from neural stem cells (NSCs) has
been suggested to be decreased in patients with schizophrenia. A similar finding was …

[HTML][HTML] Caffeine consumption and schizophrenia: A highlight on adenosine receptor–independent mechanisms

L Huang, B Sperlágh - Current opinion in pharmacology, 2021 - Elsevier
Schizophrenia is a common psychiatric disorder which affects approximately 1% of the
population worldwide. However, the complexity of etiology, treatment resistance and side …