Cancer pain, especially pain caused by metastasis to bone, is a severe type of pain, and
unless the cause and consequences can be resolved, the pain will become chronic. As …

Chronic pain is a highly prevalent debilitating condition for which treatment options remain
limited for many patients. Ionotropic ATP signalling through excitatory and calcium …

Accumulating evidence suggests that activation of spinal microglia contributes to the
development of inflammatory and neuropathic pain. However, the role of spinal microglia in …

Neuropathic cancer pain (NCP), commonly encountered in clinical practice, may be cancer‐
related, namely resulting from nervous system tumor invasion, surgical nerve damage …

Cancer-induced bone pain (CIBP) is common and challenging to treat. Common therapies,
such as opioids, radiotherapy and bisphosphonates, are often only partially effective. CIBP …

Purpose Cancer-induced bone pain (CIBP) affects one third of patients with cancer.
Radiotherapy remains the gold-standard treatment; however, laboratory and clinical work …

Cancer pain is a serious health problem, and imposes a great burden on the lives of patients
and their families. Pain can be associated with delay in treatment, denial of treatment, or …

Background: Astrocytes and metabotropic glutamate receptors play important roles in
nociceptive processing. However, their roles in bone cancer pain were not well understood …

Bone cancer induced dynamic changes of A-type K+ channels in dorsal root ganglion
neurons. Diclofenac antagonized bone cancer pain by upregulating peripheral A-type K+ …

In attempt to understand the underlying mechanisms of cancer-induced bone pain, we
investigated the presence of two tetrodotoxin-resistant sodium channels, Nav1. 8 (SNS/PN3) …