Recent advances in the development of HBV capsid assembly modulators
B Nijampatnam, DC Liotta - Current opinion in chemical biology, 2019 - Elsevier
Hepatitis B virus (HBV) infections represent a significant burden on global public health.
Current HBV treatments using nucleos (t) ide analogs (NAs) and PEG interferons cannot …
Current HBV treatments using nucleos (t) ide analogs (NAs) and PEG interferons cannot …
Discovery of small molecule therapeutics for treatment of chronic HBV infection
S Feng, L Gao, X Han, T Hu, Y Hu, H Liu… - ACS infectious …, 2018 - ACS Publications
The chronic infection of hepatitis B virus (HBV) inflicts 250 million people worldwide
representing a major public health threat. A significant subpopulation of patients eventually …
representing a major public health threat. A significant subpopulation of patients eventually …
Discovery of new small molecule hits as Hepatitis B virus capsid assembly modulators: structure and pharmacophore-based approaches
Hepatitis B virus (HBV) capsid assembly modulators (CpAMs) have shown promise as
potent anti-HBV agents in both preclinical and clinical studies. Herein, we report our efforts …
potent anti-HBV agents in both preclinical and clinical studies. Herein, we report our efforts …
Binding characteristics of pyrrole-scaffold hepatitis B virus capsid inhibitors and identification of novel potent compounds
T Ruengsatra, A Meeprasert, E Rattanangkool… - RSC …, 2023 - pubs.rsc.org
Hepatitis B virus (HBV) capsid assembly modulators (CAMs) are currently being evaluated
in clinical trials as potential curative therapies for HBV. This study used in silico …
in clinical trials as potential curative therapies for HBV. This study used in silico …
Biology of the hepatitis B virus (HBV) core and capsid assembly modulators (CAMs) for chronic hepatitis B (CHB) cure
WM McFadden, SG Sarafianos - Global Health & Medicine, 2023 - jstage.jst.go.jp
Hepatitis B virus (HBV) is a hepadnavirus, a small DNA virus that infects liver tissue, with
some unusual replication steps that share similarities to retroviruses. HBV infection can lead …
some unusual replication steps that share similarities to retroviruses. HBV infection can lead …
Identification of novel tetrahydroquinoxaline derived phenyl ureas as modulators of the hepatitis B virus nucleocapsid assembly
A key step of hepatitis B virus (HBV) replication is the selective packaging of pregenomic
RNA (pgRNA) by core protein (Cp) dimers, forming a nucleocapsid where the reverse …
RNA (pgRNA) by core protein (Cp) dimers, forming a nucleocapsid where the reverse …
The SAR-based development of small molecular HBV capsid assembly modulators
Y Wang, S Wang, X Tao, Y Wang, Y Wu… - Medicinal Chemistry …, 2022 - Springer
Hepatitis B virus (HBV) infected about 296 million people worldwidely, while clinical useful
therapeutic agents were still limited. Capsid assembly modulators (CAM) have been …
therapeutic agents were still limited. Capsid assembly modulators (CAM) have been …
The HBV capsid modulators derived from sulfamoylbenzamides and benzamides: an overview of the progress of patents
Hepatitis B virus (HBV) capsid assembly has become an attractive target for the therapy of
chronic HBV infection. Since the first report of phenylpropenamides as effective capsid …
chronic HBV infection. Since the first report of phenylpropenamides as effective capsid …