The polyamine-biosynthetic pathway represents an inviting target for the development of
agents inhibiting carcinogenesis and tumor growth. Polyamines play an essential role in the …

The polyamines putrescine, spermidine and spermine represent a group of naturally
occurring compounds exerting a bewildering number of biological effects, yet despite …

Purpose: In the current study, we sought to determine whether the addition of DFMO (α-
difluoromethyl ornithine; eflornithine), an inhibitor of ornithine decarboxylase, to a …

A number of tumour cells, including Ehrlich ascites tumour cells (EATC), possess a
polyamine uptake system which selectively accumulates endogenous polyamines and …

Treatment of HeLa cells with the polyamine biosynthesis inhibitors, methylglyoxal bis
(guanylhydrazone)(MGBG), difluoromethylornithine (DFMO) or a combination of the two …

Treatment of HeLa cells with the polyamine biosynthesis inhibitors, alpha-
difluoromethylornithine (DFMO) or methylglyoxal bis (guanylhydrazone)(MGBG), results in …

Crystals isolated from seminal fluid, subsequently identified as spermine phosphate, were
first described in 1678 by Lewenhoeck during the presentation of his treatise on …

We have previously described the synthesis and cytotoxic properties of 2 polyamine
analogues in which either the N1-or N8-amino group of spermidine was replaced by the …

Recent evidence from our laboratory and from others suggested that pretreatment with α-
difluoromethylornithine (DFMO) sensitizes some human and rodent tumor cell lines to l, 3 …

Abstract Treatment of HeLa cells with the polyamine biosynthesis inhibitors
difluoromethylornithine (DFMO) and/or methylglyoxal bis (guanylhydrazone)(MGBG) results …