Cancer cells originate from a series of acquired genetic mutations that can drive their
uncontrolled cell proliferation and immune evasion. Environmental factors, including the …

Infectious diseases are a major threat worldwide. With the alarming rise of antimicrobial
resistance and emergence of new potential pathogens, a better understanding of the …

Highlights•Salmonella enterica is comprised of non-typhoidal and typhoidal
serovars.•Typhoidal Salmonella causes enteric fever instead of self-limiting …

Primary sclerosing cholangitis (PSC) is an immune-related cholangiopathy characterized by
biliary inflammation, cholestasis, and multifocal bile duct strictures. It is associated with high …

The recent spike in the instances of complex physiological host-microbe interactions has
raised the demand for developing in vitro models that recapitulate the microbial …

Highlights•While TS persistence is mostly asymptomatic, nontyphoidal Salmonella serovars
often remain symptomatic during persistence.•Anti-inflammatory M2-like macrophages are a …

Abstract In December 2022 the US Food and Drug Administration (FDA) removed the
requirement that drugs in development must undergo animal testing before clinical …

Environmental and exogenous/endogenous factors, in a setting of individual genetic
predisposition, contribute to the cancer development. Over the years, epidemical evidence …

Introduction Typhoid toxin-expressing Salmonella enterica causes DNA damage in the
intestinal mucosa in vivo, activating the DNA damage response (DDR) in the absence of …

The intestinal epithelium is a monolayer of polarized columnar cells that act as a border
between the host and its environment and are the first line of defence against the luminal …