Bacterial type III secretion systems: specialized nanomachines for protein delivery into target cells

JE Galán, M Lara-Tejero, TC Marlovits… - Annual review of …, 2014 - annualreviews.org
One of the most exciting developments in the field of bacterial pathogenesis in recent years
is the discovery that many pathogens utilize complex nanomachines to deliver bacterially …

Bacterial type III secretion systems: a complex device for the delivery of bacterial effector proteins into eukaryotic host cells

S Wagner, I Grin, S Malmsheimer… - FEMS microbiology …, 2018 - academic.oup.com
Virulence-associated type III secretion systems (T3SS) serve the injection of bacterial
effector proteins into eukaryotic host cells. They are able to secrete a great diversity of …

Virulence determinants for Vibrio parahaemolyticus infection

L Zhang, K Orth - Current opinion in microbiology, 2013 - Elsevier
Vibrio parahaemolyticus is a marine microorganism that causes acute gastroenteritis
associated with the consumption of contaminated raw or under cooked seafood. During …

[HTML][HTML] Assembly and structure of the T3SS

BJ Burkinshaw, NCJ Strynadka - … et Biophysica Acta (BBA)-Molecular Cell …, 2014 - Elsevier
Abstract The Type III Secretion System (T3SS) is a multi-mega Dalton apparatus assembled
from more than twenty components and is found in many species of animal and plant …

Survival of the fittest: how bacterial pathogens utilize bile to enhance infection

JR Sistrunk, KP Nickerson, RB Chanin… - Clinical microbiology …, 2016 - Am Soc Microbiol
Bacterial pathogens have coevolved with humans in order to efficiently infect, replicate
within, and be transmitted to new hosts to ensure survival and a continual infection cycle. For …

Toward a Shigella Vaccine: Opportunities and Challenges to Fight an Antimicrobial-Resistant Pathogen

MM Raso, V Arato, G Gasperini, F Micoli - International journal of …, 2023 - mdpi.com
Shigellosis causes more than 200,000 deaths worldwide and most of this burden falls on
Low-and Middle-Income Countries (LMICs), with a particular incidence in children under 5 …

Broadly protective Shigella vaccine based on type III secretion apparatus proteins

FJ Martinez-Becerra, JM Kissmann… - Infection and …, 2012 - Am Soc Microbiol
Shigella spp. are food-and waterborne pathogens that cause severe diarrheal and
dysenteric disease associated with high morbidity and mortality. Individuals most often …

Surface organelles assembled by secretion systems of Gram-negative bacteria: diversity in structure and function

DG Thanassi, JB Bliska… - FEMS microbiology …, 2012 - academic.oup.com
Gram-negative bacteria express a wide variety of organelles on their cell surface. These
surface structures may be the end products of secretion systems, such as the hair-like fibers …

[HTML][HTML] The Shigella type III secretion system: an overview from top to bottom

M Muthuramalingam, SK Whittier, WL Picking… - Microorganisms, 2021 - mdpi.com
Shigella comprises four species of human-restricted pathogens causing bacillary dysentery.
While Shigella possesses multiple genetic loci contributing to virulence, a type III secretion …

Shigella and Enteroinvasive Escherichia Coli

I Belotserkovsky, PJ Sansonetti - Escherichia coli, a Versatile Pathogen, 2018 - Springer
Shigella and enteroinvasive Escherichia coli (EIEC) are gram-negative bacteria responsible
for bacillary dysentery (shigellosis) in humans, which is characterized by invasion and …