Emergence of extracellular vesicles as “liquid biopsy” for neurological disorders: boom or bust
Extracellular vesicles (EVs) have emerged as an attractive liquid biopsy approach in the
diagnosis and prognosis of multiple diseases and disorders. The feasibility of enriching …
diagnosis and prognosis of multiple diseases and disorders. The feasibility of enriching …
Post-concussion syndrome and chronic traumatic encephalopathy: narrative review on the neuropathology, neuroimaging and fluid biomarkers
I Mavroudis, D Kazis, R Chowdhury, F Petridis, V Costa… - Diagnostics, 2022 - mdpi.com
Traumatic brain injury is a significant public health issue and represents the main contributor
to death and disability globally among all trauma-related injuries. Martial arts practitioners …
to death and disability globally among all trauma-related injuries. Martial arts practitioners …
Mitochondrial dysfunction after repeated mild blast traumatic brain injury is attenuated by a mild mitochondrial uncoupling prodrug
Mild traumatic brain injury (mTBI) results in impairment of brain metabolism, which is
propagated by mitochondrial dysfunction in the brain. Mitochondrial dysfunction has been …
propagated by mitochondrial dysfunction in the brain. Mitochondrial dysfunction has been …
Traumatic brain injury and the pathways to cerebral tau accumulation
Tau is a protein that has received national mainstream recognition for its potential negative
impact to the brain. This review succinctly provides information on the structure of tau and its …
impact to the brain. This review succinctly provides information on the structure of tau and its …
Elevations in tumor necrosis factor alpha and interleukin 6 from neuronal-derived extracellular vesicles in repeated low-level blast exposed personnel
Objective The purpose of this pilot study was to determine if military service members with
histories of hundreds to thousands of low-level blast exposures (ie, experienced breachers) …
histories of hundreds to thousands of low-level blast exposures (ie, experienced breachers) …
The chronic effects of a single low-intensity blast exposure on Phosphoproteome networks and cognitive function influenced by mutant tau overexpression
Blast-induced neurotrauma (BINT) is a pressing concern for veterans and civilians exposed
to explosive devices. Affected personnel may have increased risk for long-term cognitive …
to explosive devices. Affected personnel may have increased risk for long-term cognitive …
Elevated axonal protein markers following repetitive blast exposure in military personnel
R Vorn, R Naunheim, C Lai, C Wagner… - Frontiers in …, 2022 - frontiersin.org
Blast exposures that occur during training are common in military personnel; however, the
biomarkers that relate to these subtle injuries is not well understood. Therefore, the purpose …
biomarkers that relate to these subtle injuries is not well understood. Therefore, the purpose …
The Neurovascular Unit as a Locus of Injury in Low-Level Blast-Induced Neurotrauma
GA Elder, MA Gama Sosa, R De Gasperi… - International Journal of …, 2024 - mdpi.com
Blast-induced neurotrauma has received much attention over the past decade. Vascular
injury occurs early following blast exposure. Indeed, in animal models that approximate …
injury occurs early following blast exposure. Indeed, in animal models that approximate …
Study protocol: Identifying transcriptional regulatory alterations of chronic effects of blast and disturbed sleep in United States Veterans
MJ Sullan, KA Stearns-Yoder, Z Wang, AJ Hoisington… - PLoS one, 2024 - journals.plos.org
Injury related to blast exposure dramatically rose during post-911 era military conflicts in Iraq
and Afghanistan. Mild traumatic brain injury (mTBI) is among the most common injuries …
and Afghanistan. Mild traumatic brain injury (mTBI) is among the most common injuries …
Changes in eye tracking features across periods of overpressure exposure
Introduction Repetitive exposure to blast overpressure waves can be a part of routine
military and law enforcement training. However, our understanding of the effects of that …
military and law enforcement training. However, our understanding of the effects of that …