It has been widely appreciated that numerous bacterial species express chitinases for the
purpose of degrading environmental chitin. However, chitinases and chitin-binding proteins …

Besides proteins and nucleic acids, carbohydrates are also ubiquitous building blocks of
living systems. Approximately 70% of mammalian proteins are glycosylated. Glycans not …

Metabolic oligosaccharide engineering (MOE) is a classical chemical approach to perturb,
profile and perceive glycans in physiological systems, but probes upon bioorthogonal …

Despite the rich information about the physiological state of a cell encoded in the dynamic
changes of cell-surface glycans, chemical methods to capture specific glycan epitopes at the …

Much like solving a game of Clue, understanding physiological mysteries involves
answering who, what, when and where. Multiomics approaches delve into cellular and …

The development of reliable single-cell dispensers and substantial sensitivity improvement
in mass spectrometry made proteomic profiling of individual cells achievable. Yet, there are …

The single-cell proteomics enables the direct quantification of protein abundance at the
single-cell resolution, providing valuable insights into cellular phenotypes beyond what can …

Progress in understanding long COVID and developing effective therapeutics is hampered
in part by the lack of suitable animal models. Here we used ACE2-transgenic mice …

Glycans on proteins and lipids play important roles in maturation and cellular interactions,
contributing to a variety of biological processes. Aberrant glycosylation has been associated …

The surfaces of cells and enveloped viruses alike are coated in carbohydrates that play
multifarious roles in infection and immunity. Organisms across all kingdoms of life make use …