Prevention, treatment and cure of HIV infection
RJ Landovitz, H Scott, SG Deeks - Nature Reviews Microbiology, 2023 - nature.com
The development of antiretroviral therapy for the prevention and treatment of HIV infection
has been marked by a series of remarkable successes. However, the efforts to develop a …
has been marked by a series of remarkable successes. However, the efforts to develop a …
Long-acting antiretrovirals: a new era for the management and prevention of HIV infection
P Thoueille, E Choong, M Cavassini… - Journal of …, 2022 - academic.oup.com
The long-acting antiretroviral cabotegravir and rilpivirine combination has just received FDA,
EMA and Health Canada approval. This novel drug delivery approach is about to …
EMA and Health Canada approval. This novel drug delivery approach is about to …
A systematic review of the genetic mechanisms of dolutegravir resistance
Background Characterizing the mutations selected by the integrase strand transfer inhibitor
(INSTI) dolutegravir and their effects on susceptibility is essential for identifying viruses less …
(INSTI) dolutegravir and their effects on susceptibility is essential for identifying viruses less …
Long-acting parenteral drug delivery systems for the treatment of chronic diseases
The management of chronic conditions often requires patients to take daily medication for an
extended duration. However, the need for daily dosing can lead to nonadherence to the …
extended duration. However, the need for daily dosing can lead to nonadherence to the …
Ultra-long-acting tunable biodegradable and removable controlled release implants for drug delivery
SR Benhabbour, M Kovarova, C Jones… - Nature …, 2019 - nature.com
Here we report an ultra-long-acting tunable, biodegradable, and removable polymer-based
delivery system that offers sustained drug delivery for up to one year for HIV treatment or …
delivery system that offers sustained drug delivery for up to one year for HIV treatment or …
A year-long extended release nanoformulated cabotegravir prodrug
Long-acting cabotegravir (CAB) extends antiretroviral drug administration from daily to
monthly. However, dosing volumes, injection site reactions and health-care oversight are …
monthly. However, dosing volumes, injection site reactions and health-care oversight are …
Transformation of dolutegravir into an ultra-long-acting parenteral prodrug formulation
Ultra-long-acting integrase strand transfer inhibitors were created by screening a library of
monomeric and dimeric dolutegravir (DTG) prodrug nanoformulations. This led to an 18 …
monomeric and dimeric dolutegravir (DTG) prodrug nanoformulations. This led to an 18 …
Long-acting HIV pre-exposure prophylaxis (PrEP) approaches: recent advances, emerging technologies, and development challenges
V Agrahari, SM Anderson, MM Peet… - Expert opinion on …, 2022 - Taylor & Francis
Introduction Poor or inconsistent adherence to daily oral pre-exposure prophylaxis (PrEP)
has emerged as a key barrier to effective HIV prevention. The advent of potent long-acting …
has emerged as a key barrier to effective HIV prevention. The advent of potent long-acting …
Aggregation-induced emission (AIE) fluorophores as imaging tools to trace the biological fate of nano-based drug delivery systems
The vigorous development of nanotechnology has been accompanied by an equally strong
interest and research efforts in nano-based drug delivery systems (NDDSs). However, only a …
interest and research efforts in nano-based drug delivery systems (NDDSs). However, only a …
Characterization of a reservoir-style implant for sustained release of tenofovir alafenamide (TAF) for HIV pre-exposure prophylaxis (PrEP)
Long-acting (LA) HIV pre-exposure prophylaxis (PrEP) offers the potential to improve
adherence by lowering the burden of daily or on-demand regimens of antiretroviral (ARV) …
adherence by lowering the burden of daily or on-demand regimens of antiretroviral (ARV) …