The transcription factor p53 is an important regulator of a multitude of cellular processes. In
the presence of genotoxic stress, p53 is activated to facilitate DNA repair, cell cycle arrest …

While fruits and vegetables are recommended for prevention of cancer and other diseases,
their active ingredients (at the molecular level) and their mechanisms of action less well …

It is estimated that nearly one-third of all cancer deaths in the United States could be
prevented through appropriate dietary modification. Various dietary antioxidants have …

Natural products remain an important source of new drugs, new drug leads and new
chemical entities. The plant based drug discovery resulted mainly in the development of …

Despite being the subject of extensive research and clinical trials, neuroblastoma remains a
major therapeutic challenge in pediatric oncology. The p53 protein is a central safeguard …

Background Soy and red clover isoflavones are controversial due to purported estrogenic
activity and possible effects on breast cancer. We conducted a systematic review of soy and …

Purpose Panax ginseng and its extracts have long been used for medical purposes; there is
increasing interest in developing ginseng products as cancer preventive or therapeutic …

The oncoprotein MDM2, a major ubiquitin E3 ligase of tumor suppressor p53, has been
suggested as a novel target for human cancer therapy based on its p53-dependent and p53 …

As a major negative regulator of p53, the MDM2 oncogene plays an important role in
carcinogenesis and tumor progression. MDM2 promotes p53 proteasomal degradation and …

Accumulating data clearly indicate that induction of apoptosis is an important event for
chemoprevention of cancer by naturally occurring dietary agents. In mammalian cells …