Abstract The Rotterdam Study is an ongoing prospective cohort study that started in 1990 in
the city of Rotterdam, The Netherlands. The study aims to unravel etiology, preclinical …

Abstract The Rotterdam Study is a prospective cohort study ongoing since 1990 in the city of
Rotterdam in The Netherlands. The study targets cardiovascular, endocrine, hepatic …

Precision medicine uses innovative approaches to improve disease prevention and
treatment outcomes by taking into account people's genetic backgrounds, environments …

Antidepressants (ADs) include drugs of various pharmacological groups, which are mainly
used for the treatment of mental disorders (major depressive disorder, obsessive …

QT interval length is an important risk factor for adverse cardiovascular outcomes; however,
the genetic architecture of QT interval remains incompletely understood. We conducted a …

Objective Bevacizumab, a monoclonal antibody to VEGF, has shown efficacy in ovarian,
cervical and endometrial cancer in addition to several other solid tumors. Serious side …

Background Adverse outcomes including myocardial infarction and stroke render coronary
artery disease (CAD) a leading cause of death worldwide. Biomarkers that predict such …

In essence, pharmacogenetic research is aimed at discovering variants of importance to
gene‐treatment interaction. However, epidemiological studies are rarely set up with this goal …

Синдром удлиненного интервала QT (СУИ QT) может быть как врожденным, так и
приобретенным, причем последний наиболее часто вызывается воздействием …

Genome-wide association studies have shed light on the association between natural
genetic variation and cardiovascular traits. However, linking a cardiovascular trait …