Sensory neurons with cell bodies situated in dorsal root ganglia convey information from
external or internal sites of the body such as actual or potential harm, temperature or muscle …

Infection with Mycobacterium ulcerans results in a necrotising skin disease known as a
Buruli ulcer, the pathology of which is directly linked to the bacterial production of the toxin …

Peripheral nerve damage initiates a complex series of structural and cellular processes that
culminate in chronic neuropathic pain. The recent success of a type 2 angiotensin II (Ang II) …

Injury, inflammation, and nerve damage initiate a wide variety of cellular and molecular
processes that culminate in hyperexcitation of sensory nerves, which underlies chronic …

Buruli ulcer is a noncontagious disabling cutaneous and subcutaneous mycobacteriosis
reported by 33 countries in Africa, Asia, Oceania, and South America. The causative agent …

From their observation of necrotic areas around bacterial foci in Buruli ulcers (BUs), Connor
and co-workers were the first, back in 1965, to suggest that M. ulcerans may produce a …

The skin is innervated by numerous sensory afferent neurons that respond to a diverse array
of stimuli ranging from gentle touch to noxious pain. Various features of the immune system …

Mycolactone, a polyketide molecule produced by Mycobacterium ulcerans, is the etiological
agent of Buruli ulcer. This lipid toxin is endowed with pleiotropic effects, presents cytotoxic …

Mycolactones are a group of macrolides excreted by the human pathogen Mycobacterium
ulcerans, which exhibit cytotoxic, immunosuppressive and analgesic properties. As the …

ABSTRACT Introduction Pharmacological treatment of Buruli ulcer (Mycobacterium ulcerans
infection; BU) is highly effective, as shown in two randomized trials in Africa. Areas covered …