Polyunsaturated fatty acids and fatty acid-derived lipid mediators: Recent advances in the understanding of their biosynthesis, structures, and functions
Polyunsaturated fatty acids (PUFAs) are structural components of membrane phospholipids,
and influence cellular function via effects on membrane properties, and also by acting as a …
and influence cellular function via effects on membrane properties, and also by acting as a …
Formation, signaling and occurrence of specialized pro-resolving lipid mediators—what is the evidence so far?
Formation of specialized pro-resolving lipid mediators (SPMs) such as lipoxins or resolvins
usually involves arachidonic acid 5-lipoxygenase (5-LO, ALOX5) and different types of …
usually involves arachidonic acid 5-lipoxygenase (5-LO, ALOX5) and different types of …
Resolution pharmacology: focus on pro-resolving annexin A1 and lipid mediators for therapeutic innovation in inflammation
M Perretti, J Dalli - Annual Review of Pharmacology and …, 2023 - annualreviews.org
Chronic diseases that affect our society are made more complex by comorbidities and are
poorly managed by the current pharmacology. While all present inflammatory …
poorly managed by the current pharmacology. While all present inflammatory …
Resolvin T-series reduce neutrophil extracellular traps
The newly identified 13-series (T-series) resolvins (RvTs) regulate phagocyte functions and
accelerate resolution of infectious inflammation. Because severe acute respiratory syndrome …
accelerate resolution of infectious inflammation. Because severe acute respiratory syndrome …
SARS-CoV-2 infection and lung regeneration
F Zhao, Q Ma, Q Yue, H Chen - Clinical Microbiology Reviews, 2022 - Am Soc Microbiol
The lung is the primary site of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-
2)-induced immunopathology whereby the virus enters the host cells by binding to …
2)-induced immunopathology whereby the virus enters the host cells by binding to …
E-series resolvin metabolome, biosynthesis and critical role of stereochemistry of specialized pro-resolving mediators (SPMs) in inflammation-resolution: Preparing …
The COVID-19 pandemic has raised international awareness of the importance of rigorous
scientific evidence and the havoc caused by uncontrolled excessive inflammation. Here we …
scientific evidence and the havoc caused by uncontrolled excessive inflammation. Here we …
Pulmonary delivery of specialized pro-resolving mediators-based nanotherapeutics attenuates pulmonary fibrosis in preclinical animal models
Pulmonary fibrosis (PF) is a chronic lung disease characterized by excess extracellular
matrix deposition and prolonged inflammation that fails to resolve and is druggable. Using …
matrix deposition and prolonged inflammation that fails to resolve and is druggable. Using …
Pneumonia-induced inflammation, resolution and cardiovascular disease: causes, consequences and clinical opportunities
C Stotts, VF Corrales-Medina, KJ Rayner - Circulation research, 2023 - Am Heart Assoc
Pneumonia is inflammation in the lungs, which is usually caused by an infection. The
symptoms of pneumonia can vary from mild to life-threatening, where severe illness is often …
symptoms of pneumonia can vary from mild to life-threatening, where severe illness is often …
Glucocorticoids regulate lipid mediator networks by reciprocal modulation of 15-lipoxygenase isoforms affecting inflammation resolution
Z Rao, E Brunner, B Giszas… - Proceedings of the …, 2023 - National Acad Sciences
Glucocorticoids (GC) are potent anti-inflammatory agents, broadly used to treat acute and
chronic inflammatory diseases, eg, critically ill COVID-19 patients or patients with chronic …
chronic inflammatory diseases, eg, critically ill COVID-19 patients or patients with chronic …
Dysregulated plasma lipid mediator profiles in critically ill COVID-19 patients
Coronavirus disease (COVID)-19, as a result of Severe Acute Respiratory Syndrome
Coronavirus 2 (SARS-CoV-2) infection, has been the direct cause of over 2.2 million deaths …
Coronavirus 2 (SARS-CoV-2) infection, has been the direct cause of over 2.2 million deaths …