Purine nucleoside phosphorylase (PNP) is one of the most important enzymes of the purine
metabolism, wich promotes the recycling of purine bases. Nowadays is the actual to search …

Although several different enzymes with 5′-nucleotidase activity have been described in
mammalian cells, their functions in nucleotide metabolism have not been clearly …

Twenty-seven patients with B-cell chronic lymphocytic leukemia (CLL) or a related lymphoid
malignancy were treated with high-dose cytosine arabinoside (ara-C) at a dosage of 3 …

Various 5´-nucleotidases (EC 3.1. 3.5) exist in vertebrate tissues. The sequence and cDNA
cloning of the membrane-bound ecto-5´-nucleotidase (eN) and one of the cytosolic …

Пуриннуклеозидфосфорилаза (ПНФ) является одним из важнейших ферментов
метаболизма пуринов, который способствует утилизации пуриновых оснований. В …

Of the various species of cellular 5′-nucleotidases, membranous, lysosomal and cytosolic,
only the latter are likely to play a role in the physiologic dephosphorylation of the 5 …

Research on adenosine has a long history, and since the beginning more than 80 years ago
there has been a link to energy metabolism. This is due to the fact that levels of adenosine …

Human peripheral lymphocytes incubated with 2'-deoxycoformycin and 2'-deoxyadenosine
(dAdo) reached a plateau in dATP accumulation after 4 hr that lasted for up to 24 hr. Total …

Murine T lymphocytes were separated by “panning” into four subpopulations, according to
their Lyt2 and L3T4 phenotypes: Lyt2+ L3T4+, Lyt2− L3T4−, Lyt2+ L3T4−, and Lyt2− L3T4+ …

1. Rat spleen cytosolic deoxynucleotidase was purified 40,000-fold to almost homogeneity
and had a specific activity of 3000 mumols/min per mg. 2. Molecular mass of the native …