The nuclear factor of activated T cells (NFAT) family of transcription factors, which includes
NFAT1, NFAT2, and NFAT4, are well-known to play important roles in T cell activation. Most …

Human NK cells are innate immune effectors that play a critical roles in the control of viral
infection and malignancy. The importance of their homeostasis and function can be …

Background & aims Monogenic forms of inflammatory bowel disease (IBD) illustrate the
essential roles of individual genes in pathways and networks safeguarding immune …

Common variable immunodeficiency (CVID), characterized by recurrent infections, is the
most prevalent symptomatic antibody deficiency. In∼ 90% of CVID-affected individuals, no …

Rare, monogenetic diseases present unique models to dissect gene functions and
biological pathways, concomitantly enhancing our understanding of the etiology of complex …

The transcription factor NFAT5, also known as TonEBP, belongs to the family of Rel
homology domain-containing factors, which comprises the NF-κB proteins and the …

MHCII in antigen-presenting cells (APCs) is a key regulator of adaptive immune responses.
Expression of MHCII genes is controlled by the transcription coactivator CIITA, itself …

The study was aimed to analyze expression of nuclear factor of activated T cells (NFATs),
forkhead box P3 (FOXP3), and their associated genes (sCTLA4, flCTLA4, IL10, TGFB, IL2 …

The skin can serve as an interstitial Na+ reservoir. Local tissue Na+ accumulation increases
with age, inflammation and infection. This increased local Na+ availability favors pro …

There are now 354 inborn errors of immunity (primary immunodeficiency diseases (PIDDs))
with 344 distinct molecular etiologies reported according to the International Union of …