L-asparaginases (EC 3.5. 1.1) are a family of enzymes that catalyze the hydrolysis of L-
asparagine to L-aspartic acid and ammonia. These proteins with different biochemical …

l-Asparaginases have remained an intriguing research topic since their discovery∼ 120
years ago, especially after their introduction in the 1960s as very efficient antileukemic …

l-Asparaginase (EC 3.5. 1.1) was first used as a component of combination drug therapies to
treat acute lymphoblastic leukemia (ALL), a cancer of the blood and bone marrow, almost 50 …

Abstract L-Asparaginase (L-ASNase EC 3.5. 1.1) is considered as an important
biopharmaceutical drug enzyme in the treatment of childhood acute lymphoblastic leukemia …

L-asparaginase (L-ASNase) is a vital enzyme with a broad range of applications in
medicine, food industry, and diagnostics. Among various organisms expressing L-ASNases …

Nitrogen metabolism is an important physiological process that affects the survival and
virulence of Mycobacterium tuberculosis. M. tuberculosis's utilization of nitrogen in the …

An extracellular l-asparaginase produced by a protease-deficient isolate, Bacillus
aryabhattai ITBHU02, was purified to homogeneity using ammonium sulfate fractionation …

N-terminal nucleophile (Ntn)-hydrolases catalyze the cleavage of amide bonds in a variety
of macromolecules, including the peptide bond in proteins, the amide bond in N-linked …

l-asparaginases catalyze the asparagine hydrolysis to aspartate. These enzymes play an
important role in the treatment of acute lymphoblastic leukemia because these cells are …

Abstract l-Asparaginase (l-ASNase) is a key enzyme used to treat acute lymphoblastic
leukemia, a childhood blood cancer. Here, we report on the characterization of a …