The Huisgen 1, 3-dipolar cycloaddition reaction of organic azides and alkynes1, 2 has
gained considerable attention in recent years due to the introduction in 2001 of Cu (1) …

Pioneered by Huisgen in the 1960s, 1 the 1, 3-dipolar cycloaddition reaction between
acetylenes and azides was brought back into focus by Sharpless and others2 when they …

Conspectus The challenges of the 21st century demand scientific and technological
achievements that must be developed under sustainable and environmentally benign …

Despite enormous progress in the field of the synthetic chemistry involving, for example,
catalytic and combinatorial synthesis of a large libraries of compounds, multicomponent …

The Nobel Prize in Chemistry 2022 was awarded jointly to Carolyn R. Bertozzi, Morten
Meldal, and K. Barry Sharpless “for the development of click chemistry and bioorthogonal …

In this review, the synthesis and application of biomedical and pharmaceutical polymers
synthesized via the copper (I)-catalyzed alkyne-azide cycloaddition, the thiol− ene reaction …

The ability to synthesise small peptidomimetics that mimic the secondary structure of
proteins is an ever expanding area of research directed at sourcing new medicinal agents …

Protein ADP-ribosyltransferases catalyze the transfer of adenosine diphosphate ribose (ADP-
ribose) from nicotinamide adenine dinucleotide (NAD) onto specific target proteins. Sirtuins …

Herein we describe the synthesis and rheological characterization of a series of
enzymatically sensitive PEG and peptide-based hydrogels by the Cu (I)-catalyzed 1, 3 …

The copper-catalyzed azide–alkyne cycloaddition (CuAAC) reaction is a powerful tool for
bioconjugation of biomolecules, particularly proteins and peptides. The major drawback …