Asthma is the most common treatable chronic disease of the lung affecting all age groups;
yet its treatability-despite improvements in the potency and selectivity of the drugs used and …

We tested the hypothesis that particulate air pollutants are associated with metals that have
a capacity to transport electrons and that biologic activity of the particulates can correlate …

To determine whether asthmatic subjects have an increase in airway wall thickness that
could enhance airway narrowing during bronchoprovocation, we examined the relationship …

Mortality and hospital admission rates for asthma have increased in most developed
countries over the last 30 years. Many of these countries experienced an epidemic of deaths …

This study was designed to determine if there is residual airflow obstruction and/or airway
hyperresponsiveness in adults with symptomatic asthma remission, and if age at remission …

In this study we investigated the effect of the selective and potent thromboxane A2 (TxA2)
receptor antagonist GR32191 on smooth muscle contraction induced by the TxA2 analogue …

Theophylline has been shown by several investigators to attenuate the late asthmatic
response (LAR) to inhaled allergen, suggesting that it has anti-inflammatory or …

OBJECTIVES--To explore the morbidity of patients diagnosed as asthmatic in general
practice, to examine the determinants of this morbidity, and to derive a simple morbidity …

Substantial evidence indicates that airway hyperresponsiveness in asthma is associated
with the inflammatory response directed toward the airway epithelium and submucosa …

Using serial bronchoalveolar lavage (BAL), we have studied changes in the airway
inflammatory cell populations in 20 asthmatic patients, before and after treatment with …