Interspecific competition can drive plasmid loss from a focal species in a microbial community

D Sünderhauf, U Klümper, WH Gaze… - The ISME …, 2023 - academic.oup.com
Plasmids are key disseminators of antimicrobial resistance genes and virulence factors, and
it is therefore critical to predict and reduce plasmid spread within microbial communities. The …

Fitness effects of plasmids shape the structure of bacteria–plasmid interaction networks

A Newbury, B Dawson, U Klümper… - Proceedings of the …, 2022 - National Acad Sciences
Antimicrobial resistance (AMR) genes are often carried on broad host range plasmids, and
the spread of AMR within microbial communities will therefore depend on the structure of …

Provable Boolean interaction recovery from tree ensemble obtained via random forests

M Behr, Y Wang, X Li, B Yu - Proceedings of the National …, 2022 - National Acad Sciences
Random Forests (RFs) are at the cutting edge of supervised machine learning in terms of
prediction performance, especially in genomics. Iterative RFs (iRFs) use a tree ensemble …

Testing for the fitness benefits of natural transformation during community-embedded evolution

M Winter, K Harms, PJ Johnsen, A Buckling… - …, 2023 - microbiologyresearch.org
Natural transformation is a process where bacteria actively take up DNA from the
environment and recombine it into their genome or reconvert it into extra-chromosomal …

Antagonistic mobile genetic elements can counteract each other's effects on microbial community composition

M Castledine, A Newbury, R Lewis, C Hacker… - Mbio, 2023 - Am Soc Microbiol
ABSTRACT Bacteriophages (“phages”) are hypothesized to be key drivers of bacterial
population dynamics, driving microbial community composition, but empirical support for this …

Convergent structure with divergent adaptations in combinatorial microbiome communities

M Taylor, L Janasky, N Vega - FEMS Microbiology Ecology, 2022 - academic.oup.com
Adaptation of replicate microbial communities frequently produces shared trajectories of
community composition and structure. However, divergent adaptation of individual …

Diversity loss from multiple interacting disturbances is regime‐dependent

L Lear, H Inamine, K Shea, A Buckling - Ecology Letters, 2023 - Wiley Online Library
Anthropogenic activities expose many ecosystems to multiple novel disturbances
simultaneously. Despite this, how biodiversity responds to simultaneous disturbances …

Disturbances can facilitate prior invasions more than subsequent invasions in microbial communities

L Lear, E Hesse, A Buckling - Ecology Letters, 2024 - Wiley Online Library
Invasions are commonly found to benefit from disturbance events. However, the importance
of the relative timing of the invasion and disturbance for invader success and impact on …

Interspecific competition can drive the loss of conjugative plasmids from a focal species in a microbial community

D Walker-Sünderhauf, U Klümper, WH Gaze… - bioRxiv, 2022 - biorxiv.org
Plasmids are key disseminators of antimicrobial resistance genes and virulence factors, and
it is therefore critical to predict and reduce plasmid spread within microbial communities. The …

[PDF][PDF] Context-Dependent Acquisition of Antimicrobial Resistance Mechanisms

M Winter - 2024 - ore.exeter.ac.uk
Natural transformation is a process whereby bacteria actively take up free DNA from the
environment while in a physiological state termed competence. Uptaken DNA is then …