Directed evolution of stereo‐, regio‐, and chemoselective enzymes constitutes a unique way
to generate biocatalysts for synthetically interesting transformations in organic chemistry and …

The term B-factor, sometimes called the Debye–Waller factor, temperature factor, or atomic
displacement parameter, is used in protein crystallography to describe the attenuation of X …

The free energy landscape concept that describes enzymes as an ensemble of differently
populated conformational sub-states in dynamic equilibrium is key for evaluating enzyme …

Protein stability and evolvability influence each other. Although protein dynamics play
essential roles in various catalytically important properties, their high flexibility and diversity …

Protein engineering is a powerful strategy for enhancing the properties of enzymes for
industrial applications. However, thermostabilizing an enzyme via this strategy while …

Proteins are one of the most important and resourceful biomolecules that find applications in
health, industry, medicine, research, and biotechnology. Given its tremendous relevance …

Abstract Reductive desymmetrization of 2, 2-disubstituted prochiral 1, 3-cyclodiketones to 2,
2-disubstituted-3-hydroxycycloketones is a highly desired transformation for the construction …

Directed evolution of enzymes for the asymmetric reduction of prochiral ketones to produce
enantio‐pure secondary alcohols is particularly attractive in organic synthesis. Loops …

Several hydrolases have been described to degrade polyethylene terephthalate (PET) at
moderate temperatures ranging from 25° C to 40° C. These mesophilic PET hydrolases …

Understanding the thermostability of cellulases is of high importance for their application in
lignocellulosic biomass degradation, feedstock, and pulp and paper production. Cellulases …