Synapses are specialized junctions between neurons in brain that transmit and compute
information, thereby connecting neurons into millions of overlapping and interdigitated …

The neurotransmitters GABA and glycine mediate fast synaptic inhibition by activating ligand-
gated chloride channels—namely, type A GABA (GABAA) and glycine receptors. Both types …

Synapse organizing proteins are multifaceted molecules that coordinate the complex
processes of brain development and plasticity at the level of individual synapses. Their …

GABAA receptors (GABAAR s) are ligand‐gated Cl− channels that mediate most of the fast
inhibitory neurotransmission in the central nervous system (CNS). Multiple GABAAR …

Chemical synapses provide a vital foundation for neuron-neuron communication and overall
brain function. By tethering closely apposed molecular machinery for presynaptic …

The neurexin family of cell adhesion proteins consists of three members in vertebrates and
has homologs in several invertebrate species. In mammals, each neurexin gene encodes an …

A fundamental physical interaction exists across the synapse. It is mediated by synaptic
adhesion molecules, and is among the earliest and most indispensable of molecular events …

Neuroligins are postsynaptic cell-adhesion molecules that bind presynaptic neurexins and
are genetically linked to autism. Neuroligins are proposed to organize synaptogenesis …

Neuroligins are evolutionarily conserved postsynaptic cell adhesion molecules that interact
with presynaptic neurexins. Neurons express multiple neuroligin isoforms that are targeted …

Postsynaptic organizational protein complexes play central roles both in orchestrating
synapse formation and in defining the functional properties of synaptic transmission that …