Priming approaches to improve the efficacy of mesenchymal stromal cell-based therapies

NC Noronha, A Mizukami, C Caliári-Oliveira… - Stem cell research & …, 2019 - Springer
Multipotent mesenchymal stromal cells (MSC) have been widely explored for cell-based
therapy of immune-mediated, inflammatory, and degenerative diseases, due to their …

Additive manufacturing of porous magnesium alloys for biodegradable orthopedic implants: Process, design, and modification

B Peng, H Xu, F Song, P Wen, Y Tian… - Journal of Materials …, 2024 - Elsevier
Biodegradable magnesium (Mg) alloys exhibit excellent biocompatibility, adequate
mechanical properties, and osteogenic effect. They can contribute to complete recovery of …

Mesenchymal stem cell perspective: cell biology to clinical progress

MF Pittenger, DE Discher, BM Péault… - NPJ Regenerative …, 2019 - nature.com
The terms MSC and MSCs have become the preferred acronym to describe a cell and a cell
population of multipotential stem/progenitor cells commonly referred to as mesenchymal …

Biological functions of mesenchymal stem cells and clinical implications

A Naji, M Eitoku, B Favier, F Deschaseaux… - Cellular and Molecular …, 2019 - Springer
Mesenchymal stem cells (MSCs) are isolated from multiple biological tissues—adult bone
marrow and adipose tissues and neonatal tissues such as umbilical cord and placenta. In …

Mesenchymal stem cell secretome: toward cell-free therapeutic strategies in regenerative medicine

FJ Vizoso, N Eiro, S Cid, J Schneider… - International journal of …, 2017 - mdpi.com
Earlier research primarily attributed the effects of mesenchymal stem cell (MSC) therapies to
their capacity for local engrafting and differentiating into multiple tissue types. However …

Potential pre-activation strategies for improving therapeutic efficacy of mesenchymal stem cells: current status and future prospects

M Li, Y Jiang, Q Hou, Y Zhao, L Zhong, X Fu - Stem cell research & …, 2022 - Springer
Mesenchymal stem cell (MSC)-based therapy has been considered as a promising
approach targeting a variety of intractable diseases due to remarkable multiple effect of …

Senescence in human mesenchymal stem cells: functional changes and implications in stem cell-based therapy

V Turinetto, E Vitale, C Giachino - International journal of molecular …, 2016 - mdpi.com
Regenerative medicine is extensively interested in developing cell therapies using
mesenchymal stem cells (MSCs), with applications to several aging-associated diseases …

Scaffold-free cell-based tissue engineering therapies: advances, shortfalls and forecast

A De Pieri, Y Rochev, DI Zeugolis - NPJ Regenerative Medicine, 2021 - nature.com
Cell-based scaffold-free therapies seek to develop in vitro organotypic three-dimensional
(3D) tissue-like surrogates, capitalising upon the inherent capacity of cells to create tissues …

Defining physiological normoxia for improved translation of cell physiology to animal models and humans

TP Keeley, GE Mann - Physiological reviews, 2019 - journals.physiology.org
The extensive oxygen gradient between the air we breathe (Po2~ 21 kPa) and its ultimate
distribution within mitochondria (as low as~ 0.5–1 kPa) is testament to the efforts expended …

[HTML][HTML] Oxygen in stem cell biology: a critical component of the stem cell niche

A Mohyeldin, T Garzón-Muvdi, A Quiñones-Hinojosa - Cell stem cell, 2010 - cell.com
The defining hallmark of stem cells is their ability to self-renew and maintain multipotency.
This capacity depends on the balance of complex signals in their microenvironment. Low …