Corneal nerves in health and disease

BS Shaheen, M Bakir, S Jain - Survey of ophthalmology, 2014 - Elsevier
Corneal nerves are responsible for the sensations of touch, pain, and temperature and play
an important role in the blink reflex, wound healing, and tear production and secretion …

Understanding neuropathic corneal pain—gaps and current therapeutic approaches

S Goyal, P Hamrah - Seminars in ophthalmology, 2016 - Taylor & Francis
The richly innervated corneal tissue is one of the most powerful pain generators in the body.
Corneal neuropathic pain results from dysfunctional nerves causing perceptions such as …

What causes eye pain?

C Belmonte, MC Acosta, J Merayo-Lloves… - Current ophthalmology …, 2015 - Springer
Eye pain is an unpleasant sensory and emotional experience including sensory-
discriminative, emotional, cognitive, and behavioral components and supported by distinct …

Neuropathic corneal pain: approaches for management

G Dieckmann, S Goyal, P Hamrah - Ophthalmology, 2017 - Elsevier
Neuropathic pain is caused by a primary lesion or dysfunction of the nervous system and
can occur in the cornea. However, neuropathic corneal pain (NCP) is currently an ill-defined …

Roles of IL-6 in ocular inflammation: a review

H Ghasemi - Ocular immunology and inflammation, 2018 - Taylor & Francis
Purpose: This review represents the current in vitro, in vivo animal and human researches
on the roles of IL-6 in inflammatory ocular disorders. Data sources were literature reviewed …

Corneal neurotoxicity due to topical benzalkonium chloride

J Sarkar, S Chaudhary, A Namavari… - … & visual science, 2012 - iovs.arvojournals.org
Purpose.: The aim of this study was to determine and characterize the effect of topical
application of benzalkonium chloride (BAK) on corneal nerves in vivo and in vitro. Methods …

Engineered neural tissue with Schwann cell differentiated human dental pulp stem cells: potential for peripheral nerve repair?

K Sanen, W Martens, M Georgiou… - Journal of tissue …, 2017 - Wiley Online Library
Despite the spontaneous regenerative capacity of the peripheral nervous system, large gap
peripheral nerve injuries (PNIs) require bridging strategies. The limitations and suboptimal …

Ocular surface extracellular DNA and nuclease activity imbalance: a new paradigm for inflammation in dry eye disease

S Sonawane, V Khanolkar, A Namavari… - … & visual science, 2012 - iovs.arvojournals.org
Purpose.: We determined whether nucleases are deficient in the tear fluid of dry eye disease
(DED) patients, and whether this causes extracellular DNA (eDNA) and neutrophil …

Treatment outcomes in the dry eye amniotic membrane (DREAM) study

MB McDonald, H Sheha, S Tighe, SB Janik… - Clinical …, 2018 - Taylor & Francis
Purpose To evaluate the efficacy of cryopreserved amniotic membrane (CAM) in reducing
signs and symptoms of dry eye disease (DED) in a large patient population. Methods A …

Corneal Nerve Regeneration after Self‐Retained Cryopreserved Amniotic Membrane in Dry Eye Disease

T John, S Tighe, H Sheha, P Hamrah… - Journal of …, 2017 - Wiley Online Library
Purpose. To evaluate the efficacy of self‐retained cryopreserved amniotic membrane (CAM)
in promoting corneal nerve regeneration and improving corneal sensitivity in dry eye …