Comprehensive evaluation of deep and graph learning on drug–drug interactions prediction
Recent advances and achievements of artificial intelligence (AI) as well as deep and graph
learning models have established their usefulness in biomedical applications, especially in …
learning models have established their usefulness in biomedical applications, especially in …
[HTML][HTML] Data mining of the public version of the FDA Adverse Event Reporting System
T Sakaeda, A Tamon, K Kadoyama… - International journal of …, 2013 - ncbi.nlm.nih.gov
Abstract The US Food and Drug Administration (FDA) Adverse Event Reporting System
(FAERS, formerly AERS) is a database that contains information on adverse event and …
(FAERS, formerly AERS) is a database that contains information on adverse event and …
Cardiovascular toxicities associated with immune checkpoint inhibitors: an observational, retrospective, pharmacovigilance study
Summary Background Immune checkpoint inhibitors (ICIs) have substantially improved
clinical outcomes in multiple cancer types and are increasingly being used in early disease …
clinical outcomes in multiple cancer types and are increasingly being used in early disease …
Ibrutinib-mediated atrial fibrillation attributable to inhibition of C-terminal Src kinase
Background: Ibrutinib is a Bruton tyrosine kinase inhibitor with remarkable efficacy against B-
cell cancers. Ibrutinib also increases the risk of atrial fibrillation (AF), which remains poorly …
cell cancers. Ibrutinib also increases the risk of atrial fibrillation (AF), which remains poorly …
Neurologic toxicity associated with immune checkpoint inhibitors: a pharmacovigilance study
DB Johnson, A Manouchehri, AM Haugh… - … for immunotherapy of …, 2019 - Springer
Background Immune checkpoint inhibitors (ICI) produce durable antitumor responses but
provoke autoimmune toxicities, including uncommon but potentially devastating neurologic …
provoke autoimmune toxicities, including uncommon but potentially devastating neurologic …
Cardiovascular toxicities associated with ibrutinib
JE Salem, A Manouchehri, M Bretagne… - Journal of the American …, 2019 - jacc.org
Background: Ibrutinib has revolutionized treatment for several B-cell malignancies.
However, a recent clinical trial where ibrutinib was used in a front-line setting showed …
However, a recent clinical trial where ibrutinib was used in a front-line setting showed …
Frequency and associations of adverse reactions of COVID-19 vaccines reported to pharmacovigilance systems in the European Union and the United States
D Montano - Frontiers in public health, 2022 - frontiersin.org
Introduction This study aims to provide a risk assessment of the adverse reactions related to
the COVID-19 vaccines manufactured by AstraZeneca, Janssen, Moderna, and Pfizer …
the COVID-19 vaccines manufactured by AstraZeneca, Janssen, Moderna, and Pfizer …
Psychiatric disorders associated with immune checkpoint inhibitors: a pharmacovigilance analysis of the FDA Adverse Event Reporting System (FAERS) database
Background With the increasing use of immune checkpoint inhibitors (ICIs) for tumour
immunotherapy, the immune-related adverse events (irAEs) caused by their collateral effect …
immunotherapy, the immune-related adverse events (irAEs) caused by their collateral effect …
Quantitative signal detection using spontaneous ADR reporting
Quantitative methods are increasingly used to analyse spontaneous reports. We describe
the core concepts behind the most common methods, the proportional reporting ratio (PRR) …
the core concepts behind the most common methods, the proportional reporting ratio (PRR) …
[HTML][HTML] Benefits and strengths of the disproportionality analysis for identification of adverse drug reactions in a pharmacovigilance database
JL Montastruc, A Sommet, H Bagheri… - British journal of …, 2011 - ncbi.nlm.nih.gov
The insufficiencies of basic (experimental) pharmacology as well as clinical trials for
studying ADRs are well known. Animal physiology often differs from that of humans. Clinical …
studying ADRs are well known. Animal physiology often differs from that of humans. Clinical …