Cancer cells adapt cellular metabolism to cope with their high proliferation rate. Instead of
primarily using oxidative phosphorylation (OXPHOS), cancer cells use less efficient …

Niclosamide is an oral antihelminthic drug used to treat parasitic infections in millions of
people worldwide. However recent studies have indicated that niclosamide may have broad …

Chemoresistant metastatic relapse of minimal residual disease plays a significant role for
poor prognosis of cancer. Growing evidence supports a critical role of cancer stem cell …

Phenotypic and functional heterogeneity is one of the most relevant features of cancer cells
within different tumor types and is responsible for treatment failure. Cancer stem cells …

Objective Ovarian cancer is the deadliest gynecologic malignancy and the fifth leading
cause of death from cancer in women in the US Since overall survival remains poor, there is …

Four main histological subtypes of ovarian cancer exist: serous (the most frequent),
endometrioid, mucinous and clear cell; in each subtype, low and high grade. The large …

The rapid development of new anticancer drugs that are safe and effective is a common goal
shared by basic scientists, clinicians and patients. The current review discusses one such …

Ovarian cancers represent the deadliest among gynecologic malignancies and are
characterized by a hierarchical structure with cancer stem cells (CSCs) endowed with self …

Purpose: Enzalutamide, a second-generation antiandrogen, was recently approved for the
treatment of castration-resistant prostate cancer (CRPC) in patients who no longer respond …

The Wnt signaling pathways are a group of signal transduction pathways that play an
important role in cell fate specification, cell proliferation and cell migration. Aberrant …