Principles and methods for transferring polygenic risk scores across global populations
Polygenic risk scores (PRSs) summarize the genetic predisposition of a complex human trait
or disease and may become a valuable tool for advancing precision medicine. However …
or disease and may become a valuable tool for advancing precision medicine. However …
Mendelian randomization for nephrologists
E Dobrijevic, A van Zwieten, K Kiryluk, AJ Grant… - Kidney international, 2023 - Elsevier
Confounding is major limitation of observational studies. Mendelian randomization (MR) is a
powerful study design that uses genetic variants as instrumental variables to enable …
powerful study design that uses genetic variants as instrumental variables to enable …
A guideline for reporting mediation analyses of randomized trials and observational studies: the AGReMA statement
Importance Mediation analyses of randomized trials and observational studies can generate
evidence about the mechanisms by which interventions and exposures may influence health …
evidence about the mechanisms by which interventions and exposures may influence health …
Long-term exposure to multiple ambient air pollutants and association with incident depression and anxiety
Importance Air pollution is increasingly recognized as an important environmental risk factor
for mental health. However, epidemiologic evidence on long-term exposure to low levels of …
for mental health. However, epidemiologic evidence on long-term exposure to low levels of …
Management and implications of severe COVID‐19 in pregnancy in the UK: data from the UK obstetric surveillance system national cohort
N Vousden, R Ramakrishnan, K Bunch… - Acta obstetricia et …, 2022 - Wiley Online Library
Introduction There is a lack of population level data on risk factors and impact of severe
COVID‐19 in pregnancy. The aims of this study were to determine the characteristics, and …
COVID‐19 in pregnancy. The aims of this study were to determine the characteristics, and …
Effects of prenatal exposure to maternal COVID-19 and perinatal care on neonatal outcome: results from the INTERCOVID Multinational Cohort Study
F Giuliani, D Oros, RB Gunier, S Deantoni… - American journal of …, 2022 - Elsevier
Background The effect of COVID-19 in pregnancy on maternal outcomes and its association
with preeclampsia and gestational diabetes mellitus have been reported; however, a …
with preeclampsia and gestational diabetes mellitus have been reported; however, a …
Risk factors for multisystem inflammatory syndrome in children–A population-based cohort study of over 2 million children
Background Although severe acute COVID-19 is rare in children, SARS-CoV-2 infection can
trigger the novel post-infectious condition multisystem inflammatory syndrome in children …
trigger the novel post-infectious condition multisystem inflammatory syndrome in children …
[HTML][HTML] Severity of maternal infection and perinatal outcomes during periods of SARS-CoV-2 wildtype, alpha, and delta variant dominance in the UK: prospective …
N Vousden, R Ramakrishnan, K Bunch, E Morris… - BMJ …, 2022 - ncbi.nlm.nih.gov
Severity of maternal infection and perinatal outcomes during periods of SARS-CoV-2
wildtype, alpha, and delta variant dominance in the UK: prospective cohort study - PMC …
wildtype, alpha, and delta variant dominance in the UK: prospective cohort study - PMC …
[HTML][HTML] Adjustment for energy intake in nutritional research: a causal inference perspective
Background Four models are commonly used to adjust for energy intake when estimating
the causal effect of a dietary component on an outcome: 1) the “standard model” adjusts for …
the causal effect of a dietary component on an outcome: 1) the “standard model” adjusts for …
Association between socioeconomic status and health behaviour change before and after non-communicable disease diagnoses: a multicohort study
Background Behavioural risk factors of non-communicable diseases (NCDs) are socially
patterned. However, the direction and the extent to which socioeconomic status (SES) …
patterned. However, the direction and the extent to which socioeconomic status (SES) …